321704-27-2

Basic information

• Product Name: N-Benzyl-2-bromobenzenesulfonamide
• Synonyms: N-Benzyl-2-bromobenzenesulfonamide;N-Benzyl-2-bromobenzenesulphonamide
• CAS NO: 321704-27-2
• Molecular Formula: C13H12BrNO2S
• Molecular Weight: 326.21
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 321704-27-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 457°Cat760mmHg
• Flash Point: 230.2°C
• Appearance: /
• Density: 1.503g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Benzyl-2-bromobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-2-bromobenzenesulfonamide(321704-27-2)
• EPA Substance Registry System: N-Benzyl-2-bromobenzenesulfonamide(321704-27-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 321704-27-2(Hazardous Substances Data)

Usage

General Description

N-Benzyl-2-bromobenzenesulfonamide is a chemical compound with the formula C14H12BrNO2S. It is a sulfonamide derivative with a benzyl group and a bromine atom attached to a benzene ring. N-Benzyl-2-bromobenzenesulfonamide is commonly used in organic synthesis and medicinal chemistry as a building block for the production of various pharmaceuticals, particularly as a precursor for the synthesis of potential antimicrobial and antitumor agents. Its unique structure and reactivity make it a valuable tool for the creation of diverse bioactive compounds. However, it should be handled with care as it may pose health hazards and environmental risks if not properly managed and controlled.

InChI:InChI=1/C13H12BrNO2S/c14-12-8-4-5-9-13(12)18(16,17)15-10-11-6-2-1-3-7-11/h1-9,15H,10H2

Upstream product

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Downstream Products

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Relevant articles and documents

Cobalt-Catalyzed 1,4-Aryl Migration/Desulfonylation Cascade: Synthesis of α-Aryl Amides

A cobalt-catalyzed 1,4-aryl migration/disulfonylation cascade applied to α-bromo N-sulfonyl amides was developed. The reaction was highly chemoselective, allowing the preparation of α-aryl amides possessing a variety of functional groups. The method was used as the key step to synthesize an alkaloid, (±)-deoxyeseroline. Mechanistic investigations suggest a radical process.

Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis

The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99?:?1 d.r.).

Metal-free direct construction of sulfonamides via iodine- mediated coupling reaction of sodium sulfinates and amines at room temperature

A simple, practical, and metal-free protocol has been developed for the synthesis of sulfonamides from sodium sulfinates and various amines through an iodine-mediated SN bond formation reaction at room temperature. This green reaction is cost-effective, operationally straightforward, and especially proceeds under very mild conditions to afford the target products in good to excellent yields (up to 98%).