321845-13-0 Usage
Description
(5-Amino-6-chloro-pyridin-3-yl)-Methanol, with the molecular formula C6H6ClNO, is a pyridine derivative featuring an amino group and a chlorine atom. This chemical compound serves as a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds, making it a valuable asset in drug development and research applications.
Uses
Used in Pharmaceutical Synthesis:
(5-Amino-6-chloro-pyridin-3-yl)-Methanol is used as a key intermediate for the development of various pharmaceuticals. Its unique structural features and chemical properties allow for the creation of a wide range of therapeutic agents, contributing to the advancement of medical treatments.
Used in Agrochemical Production:
In the agrochemical industry, (5-Amino-6-chloro-pyridin-3-yl)-Methanol is utilized as a building block for the synthesis of compounds with pesticidal, herbicidal, and fungicidal properties. Its incorporation into these products helps improve agricultural yields and protect crops from various pests and diseases.
Used in Organic Compounds Synthesis:
(5-Amino-6-chloro-pyridin-3-yl)-Methanol is also employed as an intermediate in the production of diverse organic compounds. Its structural versatility and reactivity make it a valuable component in the synthesis of various chemical products, further expanding its applications across different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 321845-13-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,1,8,4 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 321845-13:
(8*3)+(7*2)+(6*1)+(5*8)+(4*4)+(3*5)+(2*1)+(1*3)=120
120 % 10 = 0
So 321845-13-0 is a valid CAS Registry Number.
321845-13-0Relevant articles and documents
5-Azidoimidacloprid and an acyclic analogue as candidate photoaffinity probes for mammalian and insect nicotinic acetylcholine receptors
Kagabu,Maienfisch,Zhang,Granda-Minones,Haettenschwiler,Kayser,Maetzke,Casida
, p. 5003 - 5009 (2007/10/03)
The 5-azido analogue of the major insecticide imidacloprid, 1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine (1), and an acyclic analogue, N-(5-azido-6-chloropyridin-3-ylmethyl)-N′-methyl-N″′-nitrog uanidine (2), were prepared in good yields as candidate photoaffinity probes for mammalian and insect nicotinic acetylcholine receptors (nAChRs). The essential intermediate was 5-azido-6-chloropyridin-3-ylmethyl chloride (3) prepared in two ways: from 6-chloro-5-nitronicotinic acid by selective reduction and then diazotization, and from N-(6-chloropyridin-3-ylmethyl)morpholine by an electrophilic azide introduction with lithium diisopropylamide followed by chlorine substitution of morpholine with ethyl chloroformate. Coupling of 3 with 2-nitroiminoimidazolidine gave 1. Conversion of 3 to 2 was achieved in good yields via the hexahydrotriazine intermediate 14. Fortuitously, the azido substituent in 1 and 2 increases the affinity 7-79-fold for rat brain and recombinant α4β2 nAChRs (Kis 4.4-60 nM competing with [3H](-)-nicotine) while maintaining high potency on both insect nAChRs (Drosophila and Myzus) (Kis 1-15 nM competing with [3H]imidacloprid). Azidopyridinyl compounds 1 and 2 are therefore candidate photoaffinity probes for characterization of both mammalian and insect receptors.
