321851-63-2

Basic information

• Product Name: (4R,5S)-3-{(2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]propionyl}-4-methyl-5-phenyl-2-oxazolidinone
• Synonyms: (4R,5S)-3-{(2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]propionyl}-4-methyl-5-phenyl-2-oxazolidinone
• CAS NO: 321851-63-2
• Molecular Weight: 436.508
• Mol File: 321851-63-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,5S)-3-{(2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]propionyl}-4-methyl-5-phenyl-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-3-{(2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]propionyl}-4-methyl-5-phenyl-2-oxazolidinone(321851-63-2)
• EPA Substance Registry System: (4R,5S)-3-{(2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]propionyl}-4-methyl-5-phenyl-2-oxazolidinone(321851-63-2)

Safety Data

• Hazardous Substances Data: 321851-63-2(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 

Downstream Products

• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 
• 235084-93-2 (2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]-1-propanol 
• 321851-64-3 (2S)-1-benzyloxycarbonyl-[(1S)-2-bromo-1-methylethyl]pyrrolidine 
• 321851-66-5 (2S)-1-benzyloxycarbonyl-2-[(2R)-5,5-dimethoxypent-2-yl]pyrrolidine 
• 235084-94-3 ethyl (4R)-4-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]pentanoate 
• 321851-65-4 diethyl (2R)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]propylmalonate 

Relevant articles and documents

Asymmetric synthesis of β-amino acids by addition of chiral enolates to N-Acyloxyiminium ions and application for synthesis of optically active 5-substituted 8-methylindolizidines

(Equation Presented) N-Acyloxyiminium species generated from nitrones with acyl halides are highly reactive and can undergo reaction with soft nucleophiles such as enolates. Optically active β-amino acid derivatives can be prepared using chiral enolates bearing chiral auxiliary. The usefulness of the present method is demonstrated by the enantioselective synthesis of (5R,8R,8aS)-5-cyano-8-methylindolizidine ((-)-7), which is a common key intermediate for 5-substituted 8-methylindolizidines.