321860-21-3Relevant articles and documents
Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination-cyclization
Beshore,Dinsmore
, p. 8735 - 8739 (2007/10/03)
Herein we report the efficient syntheses of 1,4-disubstituted-2,3-diketopiperazines and 1,4,5-trisubstituted-2,3-diketopiperazines, which feature a tandem reductive amination and acylation. Aliphatic and aromatic primary amines serve as viable nucleophiles under the mild reaction conditions. (C) 2000 Elsevier Science Ltd.