32203-09-1

Basic information

• Product Name: 6-bromo-2-phenyl-2,3-dihydrobenzo[d][1,3,2]diazaborinin-4(1H)-one
• Synonyms: 6-bromo-2-phenyl-2,3-dihydrobenzo[d][1,3,2]diazaborinin-4(1H)-one
• CAS NO: 32203-09-1
• Molecular Weight: 300.95
• Mol File: 32203-09-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-bromo-2-phenyl-2,3-dihydrobenzo[d][1,3,2]diazaborinin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-2-phenyl-2,3-dihydrobenzo[d][1,3,2]diazaborinin-4(1H)-one(32203-09-1)
• EPA Substance Registry System: 6-bromo-2-phenyl-2,3-dihydrobenzo[d][1,3,2]diazaborinin-4(1H)-one(32203-09-1)

Safety Data

• Hazardous Substances Data: 32203-09-1(Hazardous Substances Data)

Upstream product

• 16313-66-9 5-bromoanthranilamide 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Biological evaluation the 2-aryl-2,3-dihydrobenzodiazaborinin-4(1H)-ones as potential dual α-glucosidase and α-amylase inhibitors with antioxidant properties

The 2-aryl-2,3-dihydrobenzodiazaborinin-4(1H)-ones (azaborininone) were synthesized as analogues of the 2-arylquinazoline-4-ones and screened through enzymatic assay in vitro for inhibitory effect against α-glucosidase and α-amylase activities. These azaborininones exhibited moderate to good inhibitory effect against these enzymes compared to acarbose used as a reference standard. The results are supported by the enzyme-ligand interactions through kinetics (in vitro) and molecular docking (in silico) studies. The test compounds also exhibited significant antioxidant activity through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) free radical scavenging assays. These azaborininone derivatives exhibited no effect on the viability of the human lung cancer (A549) cell line after 24?hr and were also not toxic towards the Vero cells.