3222-56-8Relevant articles and documents
Synthesis of C-14 and C-13, H-2-labeled IKK inhibitor: [14C] and [13C4,D3]-N-(6-chloro-7-methoxy-9H-pyrido3,4- blindol-8-yl)-2-methyl-3-pyridinecarboxamide
Li, Yuexian,Plesescu, Mihaela,Prakash, Shimoga R.
, p. 789 - 799 (2007/10/03)
[14C]-N-(6-Chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2- methyl-3-pyridinecarboxamide (5B), an IKK inhibitor, was synthesized from [ 14C]-barium carbonate in two steps in an overall radiochemical yield of 41%. The intermediate, [carboxyl-14C]-2-methylnicotinic acid, was prepared by the lithiation and carbonation of 3-bromo-2-methylpyridine. [ 13C4,D3]-N-(6-chloro-7-methoxy-9H-pyrido[3,4-b] indol-8-yl)-2-methyl-3-pyridinecarboxamide (5C) was synthesized from [1,2,3,4-13C4]-ethyl acetoacetate and [D 4]-methanol in six steps in an overall yield of 2%. [ l3C4]-2-methylnicotic acid, was prepared by condensation of [13C4]-ethyl 3-aminocrotonate and acrolein, followed by hydrolysis with lithium hydroxide. Copyright