32223-62-4

Basic information

• Product Name: Benzene, 1-isocyanato-2-propoxy-
• CAS NO: 32223-62-4
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol File: 32223-62-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 1-isocyanato-2-propoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-isocyanato-2-propoxy-(32223-62-4)
• EPA Substance Registry System: Benzene, 1-isocyanato-2-propoxy-(32223-62-4)

Safety Data

• Hazardous Substances Data: 32223-62-4(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 4469-78-7 2-propoxyaniline 

Downstream Products

• 160113-43-9 (2-Propoxy-phenyl)-carbamic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-methyl-ethyl ester 
• 114559-72-7 1-((1R,3R,5S)-8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(2-propoxy-phenyl)-urea 
• 139109-10-7 (2-Propoxy-phenyl)-carbamic acid 5-hydroxy-4-oxo-4H-pyran-2-ylmethyl ester 
• 112922-89-1 (2-Propoxy-phenyl)-carbamic acid 2-morpholin-4-yl-ethyl ester; hydrochloride 

Relevant articles and documents

5-Hydroxytryptamine (5-HT3) Receptor Antagonists. 3. Ortho-Substituted Phenylureas

A novel series of potent 5-HT3 receptor antagonists, ortho-substituted phenylureas 6a-z, is described in which the 5-membered ring of the previously reported indazoles and indolines has been replaced by an intramolecular hydrogen bond.High potency was found both for carbamate 6a and urea 6b.Granatane 6c was less potent than the equivalent tropane.Phenylurea 11c lacking the ortho substituent was inactive.Whereas further substitution could not be tolerated in the aromatic ring, activity was retained with a range of O-alkyl groups, compounds 6k-t.In addition, good activity was found for ortho ester 6u and sulfonamide 6x.The ortho-substituted phenylureas can therefore be regarded as bioisosteres of the 6,5-heterocycles indole, indazole, and indoline.