322643-50-5

Basic information

• Product Name: methanesulfonic acid 3-(1-trityl-1H-imidazol-4-yl)-propyl ester
• Synonyms: methanesulfonic acid 3-(1-trityl-1H-imidazol-4-yl)-propyl ester
• CAS NO: 322643-50-5
• Molecular Weight: 446.57
• Mol File: 322643-50-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 3-(1-trityl-1H-imidazol-4-yl)-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 3-(1-trityl-1H-imidazol-4-yl)-propyl ester(322643-50-5)
• EPA Substance Registry System: methanesulfonic acid 3-(1-trityl-1H-imidazol-4-yl)-propyl ester(322643-50-5)

Safety Data

• Hazardous Substances Data: 322643-50-5(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 

Downstream Products

• 195053-88-4 2-[3-(1-trityl-1H-imidazol-4-yl)propyl]isoindoline-1,3-dione 
• 195053-89-5 4-(3-aminopropyl)-1-(triphenylmethyl)-imidazole 
• 816457-30-4 3-{[3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]amino}propan-1-ol 

Relevant articles and documents

DOUBLE-ACYLATED GLP-1 DERIVATIVES

The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1 (7-37) (SEQ ID NO: 1), a second K residue at a position corresponding to position 26 of GLP-1 (7-37), and a maximum of ten amino acid modifications as compared to GLP-1 (7-37), wherein the first K residue is designated K37, and the second K residue is designated K26, which derivative comprises two albumin binding moieties attached to K26 and K37, respectively, wherein the albumin binding moiety comprises a protracting moiety selected from: ????????Chem. 1:?????HOOC-(CH2)x-CO-* ????????Chem. 2:?????HOOC-C6H4-O-(CH2)y-CO-* ????????Chem. 3:?????R1-C6H4-(CH2)z-CO-* ????????Chem. 4:?????HOOC-C4SH2-(CH2)w-CO-* in which x is an integer in the range of 6-18, y is an integer in the range of 3-17, z is an integer in the range of 1-5, R1 is a group having a molar mass not higher than 150 Da, and w is an integer in the range of 6-18; with the proviso that when the protracting moiety is Chem. 1, the albumin binding moiety further comprises a linker of formula Chem. 5: *-NH-(CH2)2-(O-(CH2)2)k-O-(CH2)n-CO-*, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel peptides and side chain intermediates. The derivatives are suitable for oral administration.