32315-05-2

Basic information

• Product Name: Benzenamine, 4,4-(methoxyphenylmethylene)bis(N,N-dimethyl-
• CAS NO: 32315-05-2
• Molecular Formula: C₂₄H₂₈N₂O
• Molecular Weight: 360.499
• Mol File: 32315-05-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 484.7°Cat760mmHg
• Flash Point: 133°C
• Density: 1.087g/cm³
• CAS DataBase Reference: Benzenamine, 4,4-(methoxyphenylmethylene)bis(N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4,4-(methoxyphenylmethylene)bis(N,N-dimethyl-(32315-05-2)
• EPA Substance Registry System: Benzenamine, 4,4-(methoxyphenylmethylene)bis(N,N-dimethyl-(32315-05-2)

Safety Data

• Hazardous Substances Data: 32315-05-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 2437-29-8 malachite green, oxalate salt 
• 10309-95-2 malachit green 
• 57704-66-2 malachite green picrate 
• 569-64-2 Malachitgruen 
• 510-13-4 1,1-bis(4-dimethylaminophenyl)-1-phenyl-methanol 

Downstream Products

• 10489-29-9 4-(4,4'-bis-dimethylamino-trityl)-5-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 569-64-2 Malachitgruen 
• 33560-61-1 bis-(p-N,N-dimethylaminophenyl)phenylmethyl ethyl ether 
• 1714-38-1 7-methoxy-1,3,5-cycloheptatriene 
• 10309-95-2 malachit green 
• 115209-31-9 N-(4,4'-bis-dimethylamino-trityl)-aniline 
• 23308-55-6 1,1-bis-(4-dimethylamino-phenyl)-1-phenyl-ethane 

Relevant articles and documents

PH-triggered solubility and cytotoxicity changes of malachite green derivatives incorporated in liposomes for killing cancer cells

Three different malachite green leuco derivatives (MG-Xs) are incorporated in liposomes. In all three cases, a substituent (X) is covalently linked to the central carbon atom, abbreviated as MG-OH, MG-OCH3, and MG-CN. The three MG-X compounds are solubilized separately in liposome membranes and become cationic (MG+) and water soluble under acidic conditions. MG+ is consequently released from the liposome to the aqueous exterior. Their release behavior corresponds to their ionization ability: MG-OH > MG-OCH3 > MG-CN. The cellular uptake of the liposomes, the cytotoxic effect, and the location of MG+ in cancer cells are investigated using murine cells derived from colon cancer (Colon 26 cells) and human embryonic kidney cells (HEK 293 cells). The toxic effect on cancer cells is correlated to the ionization ability of MG-Xs. The liposomes effectively deliver MG+via the endocytic pathway, resulting in the cytotoxicity of liposomes containing MG-OH which is higher than that of free MG-OH and MG+. The difference in the phospholipids constituting the liposome membranes barely had an effect on the ionization ratio and the cytotoxicity of MG-OH. Confocal fluorescence microscopic observations revealed that MG+ is ultimately transported into the nuclei after being released in acidic cellular compartments.

EFFECT OF ELECTROPHILE STRUCTURE ON RITCHIE EQUATION PARAMETERS

A joint examination of the Ritchie and Hammett equations on the basis of a spectrophotometric study of the kinetics for the formation of methyl esters of triarylcarbinols and literature data on the kinetics for the formation of triarylcarbinols showed that, contrary to Ritchie's proposal, the N+ nucleophilicity parameter of any nucleophilic system depends on the selection of the standard electrophile.The merits for introducing the parameter α, which is dependent on the nature of the substrate, into the Ritchie equation were confirmed.The significant deviation of this parameter from unity observed for a series of antipyrine cations was attributed to direct polar conjugation of +C substituents with the reaction site and through-space screening of this site by antipyryl radicals.