32347-04-9

Basic information

• Product Name: (E)-1-(3-chlorophenyl)-N-phenylmethanimine
• Synonyms: (E)-1-(3-chlorophenyl)-N-phenylmethanimine
• CAS NO: 32347-04-9
• Molecular Weight: 215.682
• Mol File: 32347-04-9.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: (E)-1-(3-chlorophenyl)-N-phenylmethanimine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(3-chlorophenyl)-N-phenylmethanimine(32347-04-9)
• EPA Substance Registry System: (E)-1-(3-chlorophenyl)-N-phenylmethanimine(32347-04-9)

Safety Data

• Hazardous Substances Data: 32347-04-9(Hazardous Substances Data)

Usage

Description

(E)-1-(3-chlorophenyl)-N-phenylmethanimine, also known as 3-chloro-N-phenylbenzylideneamine, is a chemical compound with the molecular formula C13H10ClN. It is classified as an imine, which is a functional group consisting of a carbon-nitrogen double bond. (E)-1-(3-chlorophenyl)-N-phenylmethanimine is a yellow-brown crystalline solid with a melting point of around 86-90°C and a molecular weight of 217.68 g/mol. Its chemical structure consists of a phenyl group and a chlorophenyl group connected by a carbon double bond with a nitrogen atom. (E)-1-(3-chlorophenyl)-N-phenylmethanimine is known for its various uses and potential applications in chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
(E)-1-(3-chlorophenyl)-N-phenylmethanimine is used as an intermediate in the production of pharmaceuticals for its versatile chemical properties and reactivity. It plays a crucial role in the synthesis of various drugs, contributing to the development of new medications.
Used in Dye Industry:
(E)-1-(3-chlorophenyl)-N-phenylmethanimine is also utilized as a building block in the creation of dyes, where its unique chemical structure allows for the production of a range of colors and shades.
Used in Organic Synthesis:
(E)-1-(3-chlorophenyl)-N-phenylmethanimine serves as a valuable component in organic synthesis, where it can be used to construct more complex organic molecules for various applications.
Used in Medicinal Chemistry:
(E)-1-(3-chlorophenyl)-N-phenylmethanimine has been studied for its potential applications in medicinal chemistry, particularly in the development of new drugs. Its unique structure and reactivity make it a promising candidate for the creation of novel therapeutic agents.

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 62-53-3 aniline 
• 873-63-2 m-chlorobenzyl alcohol 
• 98-95-3 nitrobenzene 
• 64-10-8 phenyl carbamate 

Downstream Products

• 1427441-69-7 (1S,3R,4S)-endo-3-(3-chlorophenyl)-2-phenyl-2-azabicyclo[2.2.2]octan-5-one 
• 72867-29-9 2-(3-chlorophenyl)-2-(phenylamino) acetonitrile 
• 225506-78-5 4-methyl-2-<1-(3-chlorophenyl)-1-(phenylamino)-methyl>-3-morpholinone 
• 10359-19-0 N-(m-chlorobenzyl)aniline 
• 1616976-77-2 3-(2-(3-chlorophenyl)quinolin-4-yl)-N,2-dimethyl-N-(propan-2-yl)propanamide 

Relevant articles and documents

Nickel Complexes Bearing N,N,O-Tridentate Salicylaldiminato Ligand: Efficient Catalysts for Imines Formation via Dehydrogenative Coupling of Primary Alcohols with Amines

Treatment of salicylaldiminato ligand L1H-L2H (L1H = 2,4-di-tert-butyl-6-((quinolin-8-ylimino)methyl)phenol; L2H = 2,4-di-tert-butyl-6-(((2-(diethylamino)ethyl)imino)methyl)phenol) with Ni(OAc)2·4H2O in refluxing ethanol afforded nickel complexes [(L1)Ni(OAc)] (1) and [(L2)Ni(OAc)] (2), respectively. Reaction of L3H (L3H = (2,4-di-tert-butyl-6-(((2-(pyridin-2-yl)ethyl)imino)methyl)phenol)) with Ni(OAc)2·4H2O in the presence of excess triethylanmine gave the dual ligands coordinated nickel complex [(L2)2Ni] (3). Complexes 1-3 were well characterized by high-resolution mass spectrometry, infrared spectroscopy, elemental analysis, and X-ray diffraction analysis. All the three Ni(II) complexes exhibited efficient activity and good selectivity in the acceptorless dehydrogenative coupling of alcohols and amines to produce imines and diimines. The present protocol provides an atom-economical and sustainable route for the synthesis of various imine derivatives by employing an earth-abundant nickel salt and easily prepared salicylaldiminato ligands.

Metal-free regioselective C-H amination for the synthesis of pyrazole-containing 2H-indazoles

A general and practical regioselective approach for the C-H amination of 2H-indazoles under transition-metal-free conditions was developed. A series of substrates were tested showing eminent functional group tolerance and affording the C-N functionalization products in good to excellent yields. Mechanism studies revealed that a radical process was involved in this transformation.

Catalyst- And solvent-free efficient access to: N -alkylated amines via reductive amination using HBpin

A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and is compatible with a wide range of sterically and electronically diverse aldehydes and primary amines. Notably, this simple process offers scalability, excellent functional group tolerance, chemoselectivity, and is also effective at the synthesis of biologically relevant molecules. This journal is