323578-34-3

Basic information

• Product Name: [1-(4-NITRO-BENZYL)-PIPERIDIN-4-YL]-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: [1-(4-NITRO-BENZYL)-PIPERIDIN-4-YL]-CARBAMIC ACID TERT-BUTYL ESTER;tert-Butyl 1-(4-nitrobenzyl)piperidin-4-ylcarbamate
• CAS NO: 323578-34-3
• Molecular Formula: C₁₇H₂₅N₃O₄
• Molecular Weight: 335.4
• Mol File: 323578-34-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1-(4-NITRO-BENZYL)-PIPERIDIN-4-YL]-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(4-NITRO-BENZYL)-PIPERIDIN-4-YL]-CARBAMIC ACID TERT-BUTYL ESTER(323578-34-3)
• EPA Substance Registry System: [1-(4-NITRO-BENZYL)-PIPERIDIN-4-YL]-CARBAMIC ACID TERT-BUTYL ESTER(323578-34-3)

Safety Data

• Hazardous Substances Data: 323578-34-3(Hazardous Substances Data)

Usage

Description

[1-(4-NITRO-BENZYL)-PIPERIDIN-4-YL]-CARBAMIC ACID TERT-BUTYL ESTER is a complex organic compound with the molecular formula C16H23N3O4. It is a tert-butyl ester of carbamic acid, featuring a piperidine ring with a benzyl substituent. The presence of a nitro group attached to the benzyl group classifies it as a nitro compound. This chemical is notable for its structural features and functional groups, which may endow it with potential applications in the fields of pharmaceuticals and organic synthesis. However, due to its potential hazards and toxicity, it is crucial to handle this compound with care and adhere to safety protocols.

Uses

Used in Pharmaceutical Industry:
[1-(4-NITRO-BENZYL)-PIPERIDIN-4-YL]-CARBAMIC ACID TERT-BUTYL ESTER is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structural features and functional groups make it a promising candidate for the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Organic Synthesis:
In the field of organic synthesis, [1-(4-NITRO-BENZYL)-PIPERIDIN-4-YL]-CARBAMIC ACID TERT-BUTYL ESTER serves as a valuable building block for the creation of more complex molecules. Its versatile structure allows for further functionalization and modification, enabling the synthesis of a wide range of organic compounds with diverse applications.

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 100-14-1 4-nitrobenzyl chloride 
• 73889-19-7 tert-butyl (1-benzylpiperidin-4-yl)carbamate 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 323578-56-9 4-tert-butoxycarbonylamino-1-(4-aminobenzyl)piperidine 
• 1637586-45-8 N-(1-(4-(3-allylureido)benzyl)piperidin-4-yl)-4-chloro-2-methoxybenzamide 
• 1637586-46-9 4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide 
• 1637586-47-0 N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-fluoro-4-(trifluoromethyl)benzamide 
• 1637586-48-1 N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide 
• 1637586-49-2 4-chloro-2-methoxy-N-(1-(4-(2-oxoimidazolidin-1-yl)benzyl)piperidin-4-yl)benzamide 
• 1637586-50-5 3-fluoro-N-(1-(4-(2-oxoimidazolidin-1-yl)benzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide 
• 1637586-51-6 N-(1-(4-(2-oxoimidazolidin-1-yl)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide 
• 1637586-52-7 N-(1-(4-(3-ethylthioureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide 
• 1637586-53-8 N-(1-(4-(3-ethylthioureido)benzyl)piperidin-4-yl)-3-fluoro-4-(trifluoromethyl)benzamide 
• 1637586-54-9 4-chloro-N-(1-(4-(3-ethylthioureido)benzyl)piperidin-4-yl)-2-methoxybenzamide 
• 1637586-32-3 C₂₀H₂₀F₃N₃O₃ 
• 1637586-66-3 N-(1-(4-guanidinobenzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide 
• 1637586-67-4 3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs

Based on the hybridization of the privileged fragments in DABO and DAPY-typed HIV-1 NNRTIs, a novel series of 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives were designed, synthesized, and evaluated for their in vitro

Substituted 2-thioxothiazolidin-4-one derivatives showed protective effects against diabetic cataract via inhibition of aldose reductase

In an effort to develop a new class of potent aldose reductase inhibitors against diabetic cataracts, a series of novel 2-thioxothiazolidine-4-one derivatives was synthesized in excellent yields via a facile synthetic route. These compounds were tested against aldehyde (ALR1) and aldose reductase (ALR2) enzymes, where they showed considerable inhibitory activity. Among the tested derivatives, compound 6e showed selective and excellent inhibition of ALR2 over ALR1. The experimental diabetes was induced by the intraperitoneal administration of streptozotocin in male Wistar rats. Compound 6e showed positive modulation of body weight, blood glucose, and blood insulin levels in diabetic rats. Compound 6e also showed ALR2 inhibition as evidenced by Western blot analysis in lens homogenates of Wistar rats having cataract. The docking study of 6e was also performed inside the active site of ALR2 to enumerate the key contacts for inhibitory activity.

Exploiting the Tolerant Region i of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility an

Diarylpyrimidine derivatives (DAPYs) exhibit robust anti-HIV-1 potency, although they have been compromised by E138K variant and severe side-effects and been suffering from poor water solubility. In the present work, hydrophilic morpholine or methylsulfon