323588-31-4

Basic information

• Product Name: Benzamide, 4-chloro-N-[2,2,2-trichloro-1-[[(3-pyridinylamino)thioxomethyl]amino]eth yl]-
• CAS NO: 323588-31-4
• Molecular Formula: C15H12Cl4N4OS
• Molecular Weight: 438.164
• Mol File: 323588-31-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-chloro-N-[2,2,2-trichloro-1-[[(3-pyridinylamino)thioxomethyl]amino]eth yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-chloro-N-[2,2,2-trichloro-1-[[(3-pyridinylamino)thioxomethyl]amino]eth yl]-(323588-31-4)
• EPA Substance Registry System: Benzamide, 4-chloro-N-[2,2,2-trichloro-1-[[(3-pyridinylamino)thioxomethyl]amino]eth yl]-(323588-31-4)

Safety Data

• Hazardous Substances Data: 323588-31-4(Hazardous Substances Data)

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 17452-27-6 pyridin-3-yl isothiocyanate 
• 323588-29-0 N-(1-amino-2,2,2-trichloroethyl)-4-chlorobenzamide 

Relevant articles and documents

Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder

Thiourea derivatives were identified as glyburide-reversible potassium channel openers through high-throughput screening. Based on these findings, a number of novel cyanoguanidines were designed and synthesized, which hyperpolarized human bladder KATP channels. These agents are potent full agonists in relaxing electrically-stimulated pig bladder strips. The synthesis, SAR and biological properties of these agents are discussed.

Potassium channel openers

Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.