32365-53-0Relevant articles and documents
HETEROARYLCARBOXYLIC ACID ESTER DERIVATIVE
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Page/Page column 42-43, (2012/11/06)
The present invention provides a hyperglycemic inhibitor having a serine protease inhibitory action, which is a novel prophylactic or therapeutic drug for diabetes. A compound represented by the following formula (I), wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof
PROCESS FOR MAKING A METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATOR - 874
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Page/Page column 10-11, (2011/08/03)
Processes for making 7-methyl-5-(3piperazin-1-ylmethyl-[1,2,4]oxadiazol-5-yl)-2-(4- trifluoromethoxybenzyl)-2,3-dihydroisoindol-1-one
Intra-molecular Diels-Alder reactions of citraconamic acids from furfurylamines and citraconic anhydride: Effects of substitution in the furan ring on regioselectivity
Murali, Rajappa,Surya Prakash Rao,Scheeren, Hans W
, p. 3165 - 3174 (2007/10/03)
Regioselectivity in the intra-molecular Diels-Alder (IMDA) reaction of furfurylcitraconamic acids derived from N-benzylfurfurylamines and citraconic anhydride can be controlled by substituents located in the furan ring and by reaction conditions. Reactions conducted under kinetic conditions resulted in cycloaddition products having methyl and aminomethylene substituent in 1,3-relationship whereas under thermodynamic conditions, excepting in the case of the 3-methylsulfanyl group, the products rearranged to more stable cycloadducts in which the substituents are in 1,2-relationship. Product formation can be explained on the basis of frontier orbital interactions and steric considerations.