32388-73-1

Basic information

• Product Name: 3-Isopropylbenzophenone
• Synonyms: [3-(1-Methylethyl)phenyl]phenyl ketone;3-Isopropylbenzophenone
• CAS NO: 32388-73-1
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.3
• Mol File: 32388-73-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Isopropylbenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isopropylbenzophenone(32388-73-1)
• EPA Substance Registry System: 3-Isopropylbenzophenone(32388-73-1)

Safety Data

• Hazardous Substances Data: 32388-73-1(Hazardous Substances Data)

Upstream product

• 325770-58-9 3-isopropylbenzoyl chloride 
• 71-43-2 benzene 
• 7446-70-0 aluminium trichloride 
• 98-82-8 Isopropylbenzene 
• 98-88-4 benzoyl chloride 
• 98-95-3 nitrobenzene 
• 107-06-2 1,2-dichloro-ethane 
• 5433-01-2 1-bromo-3-isopropylbenzene 
• 30951-66-7 2-(3-bromophenyl)-2-propanol 
• 65-85-0 benzoic acid 
• 22071-15-4 ketoprofen 
• 19099-54-8 2-isopropyliodobenzene 
• 118633-39-9 Benzoesaeure--anhydrid 

Downstream Products

• 32388-75-3 m-Isopropylbenzophenon-anil 
• 32388-78-6 N-(m-Isopropylbenzhydryl)-anilin 

Relevant articles and documents

Ortho C-H acylation of aryl iodides by palladium/norbornene catalysis

Reported herein is a palladium/norbornene-catalyzed ortho-arene acylation of aryl iodides by a Catellani-type C-H functionalization. This transformation is enabled by isopropyl carbonate anhydrides, which serve as both an acyl cation equivalent and a hydride source. Double (re)agent: A palladium/norbornene-catalyzed ortho-acylation of aryl iodides was developed, and is enabled by isopropyl carbonate anhydrides, which function as both an acyl cation equivalent and a hydride source. This reaction exhibits excellent functional-group compatibility and broad substrate scope. Heterocycle moieties can be tolerated on both the aryl and acyl partners. FG=functional group.

Microwave-assisted facile and rapid friedel-crafts benzoylation of arenes catalyzed by bismuth trifluoromethanesulfonate

The catalytic activity of metal triflates was investigated in Friedel-Crafts benzoylation under microwave irradiation. Friedel-Crafts benzoylation with benzoyl chloride of a variety of arenes containing electron-rich and electron-poor rings using bismuth triflate under microwave irradiation is described. This method allows the preparation of aryl ketones under solventless conditions in good to excellent yields and short reaction time. Bismuth triflate was easily recovered and reused five times without significant loss of the catalytic activity.

Perfluoroalkanesulfonic acid catalyzed acylations of alkylbenzenes: Synthesis of alkylanthraquinones

The acylation of alkylbenzenes 1 with benzoyl chloride 2 and catalytic amounts of perfluorobutanesulfonic acid affords the corresponding 2-, 3-, and 4-alkylbenzophenones 3 with unusually high amounts of ortho products. Surprisingly, even tert-butylbenzene reacts under these reaction conditions without any acid catalyzed dealkylation. The yield of benzoylation of p-xylene 4 with benzoic acid in the presence of 5 mol% C4F9SO3H to give 2,5-dimethylbenzophenone 5 could significantly be improved from 14% to 90% by continuous removal of water formed during the acylation. Also in the preparation of alkylanthraquinones 7 by reaction of alkylbenzenes with phthalic anhydride, water removal is the decisive factor to obtain satisfactory yields for the second acylation, allowing to cyclize 6 with catalytic amounts (10 mol%) of CF3SO3H in organic solvents to the corresponding alkylanthraquinones 7.