32391-97-2Relevant articles and documents
Neighboring-Group Participation in Organic Redox Reactions. 10. The Kinetic and Mechanistic Effects of Imidazole and Benzimidazole Nitrogen on Thioether Oxidations
Williams, Keith A.,Doi, Joyce Takahashi,Musker, W. Kenneth
, p. 4 - 10 (1985)
The kinetics of the aqueous iodine oxidation of a number of imidazolyl- and benzimidazolylalkyl methyl sulfides have been studied.Evidence of neighboring-group participation has been observed in all cases.The anchimeric assistance provided by the benzimidazole moiety is evidenced by rate accelerations of 102-105.The oxidation of 1-methyl-2-imidazole, 1, is 106 times faster than that of simple thioethers and is faster than any previously reported acyclic thioether.The reaction of 2-benzimidazole is accelerated by105 via a transient N-S dication.Additionally, the pH profiles of all of the compounds studied provide strong evidence for N-S interacted intermediates.
Development of 11C-Labeled ω-sulfhydryl fatty acid tracer for myocardial imaging with PET
Wu, Xiangxiang,Wang, Peizhi,Liu, Ruixin,Zeng, Huahui,Chao, Fangfang,Liu, Hao,Xu, Caiyun,Hou, Haifeng,Yao, Qiong
, p. 1657 - 1666 (2017/11/17)
[11C]-S-methyl-16-thiopalmitic acid (a) was developed with excellent heart-to-background uptake ratios and higher retention in heart. Myocardial uptake and metabolism of the tracer is markedly higher CPT I dependent. When compared to [11C]-S-methyl-14-thiomyristic acid (b), [11C]-S-methyl-12-thiododecanoic acid (c) and [11C]-palmitate, a showed an early high uptake and a significantly slower late clearance in heart and a prolonged myocardial elimination half-life (30 min). Analysis of heart tissue and urine samples showed that a was metabolized via beta-oxidation in myocardium. Small animal PET images of the accumulation of a in the rat myocardium were clearly superior to [11C]-palmitate. These initial studies suggest that a could be a potentially useful clinical PET tracer to assess myocardial fatty acid metabolism.
8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides
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, (2008/06/13)
This invention relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides that are useful as prostaglandin antagonists and analgesic agents.