324-15-2

Basic information

• Product Name: 1H-BENZIMIDAZOLE, 2-(3-FLUOROPHENYL)-
• Synonyms: 2-(3-Fluorophenyl)benziMidazole, 95%;2-(3-Fluoro-phenyl)-1H-benzoimidazole;1H-BENZIMIDAZOLE, 2-(3-FLUOROPHENYL)-;2-(3-FLUOROPHENYL)-1H-BENZIMIDAZOLE;2-(3-FLUOROPHENYL)-1H-BENZO[D]IMIDAZOLE;2-(3-FLUOROPHENYL)-1H-BENZ[D]IMIDAZOLE
• CAS NO: 324-15-2
• Molecular Formula: C₁₃H₉FN₂
• Molecular Weight: 212.22
• Mol File: 324-15-2.mol
• Article Data: 30

Chemical Properties

• Melting Point: 258 °C
• Boiling Point: 399.8°C at 760 mmHg
• Flash Point: 195.6°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 1.33E-06mmHg at 25°C
• Refractive Index: 1.666
• PKA: 11.21±0.10(Predicted)
• CAS DataBase Reference: 1H-BENZIMIDAZOLE, 2-(3-FLUOROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-BENZIMIDAZOLE, 2-(3-FLUOROPHENYL)-(324-15-2)
• EPA Substance Registry System: 1H-BENZIMIDAZOLE, 2-(3-FLUOROPHENYL)-(324-15-2)

Safety Data

• Hazardous Substances Data: 324-15-2(Hazardous Substances Data)

Usage

Benzimidazole derivative

The compound is derived from benzimidazole, which is a heterocyclic aromatic organic compound known for its importance in medicinal chemistry.

3-fluorophenyl group

A phenyl ring (a six-carbon ring with bonded hydrogen atoms) attached to the benzimidazole ring, with a fluorine atom at the 3-position (the meta-position) of the phenyl ring.

Potential pharmaceutical applications

The compound has potential use in the development of drugs targeting specific biological pathways, making it a valuable building block for the synthesis of various biologically active compounds.

Versatile chemical

Due to its unique structure and properties, 1H-Benzimidazole, 2-(3-fluorophenyl)can be used in the synthesis of a wide range of compounds, making it a versatile chemical in medicinal chemistry.

Fluorine substituent

The presence of a fluorine atom in the compound may confer unique pharmacological properties, such as increased potency, selectivity, and metabolic stability, enhancing its potential as a drug candidate.

InChI:InChI=1/C13H9FN2/c14-10-5-3-4-9(8-10)13-15-11-6-1-2-7-12(11)16-13/h1-8H,(H,15,16)

Upstream product

• 455-38-9 3-fluorobenzoic acid 
• 95-54-5 1,2-diamino-benzene 
• 456-48-4 3-Fluorobenzaldehyde 
• 70090-82-3 1-fluoro-3-(propa-1,2-dien-1-yl)benzene 
• 455-37-8 3-fluorobenzamide 
• 615-43-0 2-iodophenylamine 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 456-47-3 3-fluoro-benzenemethanol 
• 88-74-4 2-nitro-aniline 
• 4403-69-4 2-amino-1-benzylamine 
• 615-36-1 2-bromoaniline 
• 455-36-7 1-(3-fluorophenyl)ethanone 
• 100-82-3 (3-fluorophenyl)methanamine 

Downstream Products

• 1096130-13-0 2-(3-fluorophenyl)-1-[1-(2,3,4-trifluorophenyl)-1H-[1,2,3]-triazol-4-yl-methyl]-1H-benz[d]imidazole 
• 1096130-15-2 C₂₂H₁₄F₃N₅ 
• 1096130-17-4 C₂₂H₁₅F₂N₅ 
• 1096130-19-6 C₂₃H₁₈FN₅O 
• 1096130-21-0 C₂₃H₁₈FN₅O 
• 1096130-23-2 C₂₃H₁₇F₂N₅ 
• 1096130-25-4 C₂₂H₁₄F₃N₅ 
• 1096130-29-8 C₂₃H₁₅F₄N₅ 
• 1096130-31-2 C₂₃H₁₈FN₅ 
• 1096130-33-4 C₂₃H₁₈FN₅ 
• 1096130-27-6 2-(3-fluorophenyl)-1-(1-phenyl-1H-[1,2,3]-triazol-4-yl-methyl)-1H-benzo[d]imidazole 

Relevant articles and documents

Synthesis of benzimidazole based hydrazones as non-sugar based α-glucosidase inhibitors: Structure activity relation and molecular docking

In search for α-glucosidase inhibitors used in the treatment of diabetes mellitus, a series of unique benzimidazole based hydrazones derivatives were synthesized (5a-5p), which were then investigated for their in vitro α-glucosidase inhibitory potential.

Oxidative coupling of primary amines to imines catalyzed by CoCl2·6H2O

A high-performance, readily available and eco-friendly cobalt catalyst has been suggested for the first time for the additive-free oxidative coupling of primary amines to imines. Different substituted benzylamine and heteroaryl methanamine compounds could be transformed into their corresponding imines in good to excellent yields over this catalyst. Meanwhile, it has been demonstrated that this catalyst can also afford the oxidative coupling of various benzylamines with o-phenylenediamine to produce benzimidazole derivatives in medium to good yields.

Solvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I2

A solvent-dependent I2-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles and 1,3,5-triarylbenzenes via the annulation of 2-amino anilines and aryl alkyl ketones or the cyclization of aryl alkyl ketones, respectively. With 1,4-dioxane as the solvent, sequential C[sbnd]N bond formation followed by C(CO)-C(CH3) bond cleavage leads to the formation of benzimidazoles in a highly selective manner while aldol-type self-condensation of aryl alkyl ketones predominates using PhNO2 or PhCl as the solvent to afford 1,3,5-triarylbenzenes.