324-57-2

Basic information

• Product Name: 2-(3-fluorophenyl)-5-phenyloxazole
• Synonyms: 2-(3-fluorophenyl)-5-phenyl-1,3-oxazole
• CAS NO: 324-57-2
• Molecular Formula: C₁₅H₁₀FNO
• Molecular Weight: 239.2444
• EINECS: 206-303-6
• Mol File: 324-57-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 390.8°C at 760 mmHg
• Flash Point: 190.1°C
• Appearance: /
• Density: 1.194g/cm³
• Vapor Pressure: 5.83E-06mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 2-(3-fluorophenyl)-5-phenyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-fluorophenyl)-5-phenyloxazole(324-57-2)
• EPA Substance Registry System: 2-(3-fluorophenyl)-5-phenyloxazole(324-57-2)

Safety Data

• Hazardous Substances Data: 324-57-2(Hazardous Substances Data)

Usage

General Description

2-(3-fluorophenyl)-5-phenyloxazole is a chemical compound with the molecular formula C15H10FNO. It is commonly used in research and laboratory settings as a fluorescent dye and in the synthesis of pharmaceuticals and other organic compounds. 2-(3-fluorophenyl)-5-phenyloxazole exhibits fluorescence properties and is often used as a fluorescent tag for various biological and chemical studies. It is important to handle this compound with caution and adhere to proper safety protocols, as it may pose health and environmental risks if not handled properly.

InChI:InChI=1/C15H10FNO/c16-13-8-4-7-12(9-13)15-17-10-14(18-15)11-5-2-1-3-6-11/h1-10H

Upstream product

• 455-37-8 3-fluorobenzamide 
• 122-78-1 phenylacetaldehyde 
• 100-82-3 (3-fluorophenyl)methanamine 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 304882-57-3 3-fluoro-N-(2-phenylethyl)benzamide 
• 1006-68-4 5-phenyloxazole 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 1427180-46-8 3-fluoro-N-(pivaloyloxy)benzamide 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Synthesis of 2,5-disubstituted oxazoles: Via cobalt(III)-catalyzed cross-coupling of N -pivaloyloxyamides and alkynes

An efficient synthesis of 2,5-disubstituted oxazoles via Co(iii) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.

Iodine catalysed intramolecular C(sp3)-H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Iodine catalyzed synthesis of 2,5-disubstituted oxazoles from N-arylethylamides through intramolecular C(sp3)-H functionalization under metal-free conditions is described. The method is tolerable to a wide range of substrates having a variety of functional groups with moderate to good yields of the products.

Iodine(III)-promoted synthesis of oxazoles through oxidative cyclization of N -styrylbenzamides

The hypervalent iodine reagent PhI(OTf)2, generated in situ, has been successfully utilized in an intramolecular oxidative cyclization of N-styrylbenzamides. In remarkably short reaction times, the desired 2,5-disubstituted oxazoles were isolated in high yields in this metal-free oxidative C-O bond-forming reaction. Georg Thieme Verlag Stuttgart, New York.