32405-50-8 Usage
Abbreviation
MDPD
Field of use
Neuroscience research
Function
Potent blocker of nicotinic acetylcholine receptors
Applications
a. Studying the role of nicotinic receptors in physiological and pathological processes
b. Investigating the impact of nicotinic receptors on synaptic transmission, neuromuscular function, and nicotine addiction
Chemical structure
Unique structure that contributes to its high specificity for nicotinic receptors
Research value
Valuable tool for studying molecular and cellular mechanisms of neuronal signaling and behavior
Potential applications in drug development
Disorders related to nicotinic receptor dysfunction
a. Parkinson's disease
b. Alzheimer's disease
c. Schizophrenia
Check Digit Verification of cas no
The CAS Registry Mumber 32405-50-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,4,0 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 32405-50:
(7*3)+(6*2)+(5*4)+(4*0)+(3*5)+(2*5)+(1*0)=78
78 % 10 = 8
So 32405-50-8 is a valid CAS Registry Number.
32405-50-8Relevant articles and documents
Kinetics of Base-catalysed Iodination of Substituted Acetonaphthones
Ananthakrishnanadar, P.,Gnanasekaran, C.
, p. 646 - 649 (2007/10/02)
Kinetics of iodination of 6-substituted 2-acetonaphthones and of 4-substituted 1-acetonaphthones in 20percent pyridine-20percent methanol-60percent water (v/v) have been followed at three temperatures.The Hammett equation applies very well to these reactions.The rate constants for various heterocyclic base-catalysed iodination of acetophenone and of 1- and 2-acetonaphthones in 60percent (v/v) methanol-water solvent have been correlated with pKa values of the conjugate acids of the heterocyclic bases via the Broensted equation giving β values of 0.88, 1.01 and 0.92 for acetophenone, 1-acetonaphthone and 2-acetonaphthone respectively.The influence of solvent on the rates of pyridine-catalysed iodination of acetophenone and of 1- and 2-acetonaphthones has also been studied.
