324077-91-0Relevant articles and documents
Method of Inducing Cleavage of Amyloid Precursor Protein to Form a Novel Fragment
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, (2010/07/08)
The present invention provides a method of inducing cleavage of amyloid precursor protein to produce an approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein in a subject, the method comprising administering a heterocyclic compound or a pharmaceutically acceptable salt, hydrate or prodrug thereof to a subject in need thereof, wherein the approximately 17 kilodalton fragment includes the carboxyterminal amino acid sequence of amyloid precursor protein and amyloid-beta amino acid sequence. Also provided is a screening method for identifying compounds induce cleavage of amyloid precursor protein to produce the approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein.
Azaindolizinone derivatives and cerebral function improvers containing the same as the active ingredient
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, (2008/06/13)
Azaindolizinon derivatives or pharmaceutically acceptable salts thereof represented by the formula I: wherein R1represents hydrogen atom, halogen atom or C1-C6alkyl, R2represents hydrogen atom, C1-Cs
