32410-52-9Relevant articles and documents
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Korach,Bergmann
, p. 1118,1120 (1949)
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Donor Rhodium Carbenes by Retro-Buchner Reaction
Mato, Mauro,Echavarren, Antonio M.
supporting information, p. 2088 - 2092 (2019/01/25)
Rhodium carbenes are key intermediates in a range of cycloadditions and insertion reactions. Herein, we report the first generation of donor RhII carbenes by decarbenation of 7-substituted 1,3,5-cycloheptatrienes. This discovery unlocks an improved retro-Buchner-cyclopropanation sequence, a Si?H insertion reaction for a broad-scope synthesis of allylsilanes, and a new method for the vinylogation of aldehydes. The last strategy led to the development of an iterative synthesis of E-polyenes, and to the total synthesis of navenones B and C.
5-Membered cyclic hydroxamic acids as HDAC inhibitors
Mutule, Ilze,Borovika, Diana,Rozenberga, Elina,Romanchikova, Nadezhda,Zalubovskis, Raivis,Shestakova, Irina,Trapencieris, Peteris
, p. 216 - 223 (2015/04/14)
The new histone deacylases inhibitors (HDACi) were synthesized in the class of 5-membered cyclic hydroxamic acids (5-CHA), showing medium size CHA as a new Zn-binding group. New reaction sequence was proposed for the synthesis of 5-membered alkylidene-cyc