3243-04-7Relevant articles and documents
Methylenecyclopropane Ring Formation/Opening Cascade for the Synthesis of Indolizines
Zhu, Congjun,Zhao, Peng,Qiao, Yan,Xiao, Ke,Song, Chuanjun,Chang, Junbiao
, p. 7045 - 7049 (2017/07/15)
A unique strategy toward the synthesis of polysubstituted indolizines has been developed. When 2-pyridinyl-2-(2′-bromoallyl)-1-carboxylates were treated with Cs2CO3, the starting material went through a methylenecyclopropane ring formation/opening cascade, and the corresponding indolizines were obtained in moderate to good yield as a single regioisomer.
Isocyanatophosphoric acid dichloride: A novel reagent for the introduction of a cyano group into the molecules of electron-rich heterocycles and enamines
Smaliy, Radomir V.,Chaikovskaya, Aleksandra A.,Pinchuk, Aleksandr M.,Tolmachev, Andrei A.
, p. 2416 - 2420 (2007/10/03)
A new synthetic method is developed which enables a direct one-step introduction of a cyano group into electron-rich heterocyclic systems of the indole, pyrrole, and indolizine series, and also to enamines using isocyanatophosphoryl dichloride.