32434-42-7 Usage
Description
rac-Febrifugine Dihydrochloride is a white solid salt derived from Febrifugine, a bioactive constituent found in a Chinese medicinal herb. It is known for its therapeutic activity in treating various health conditions, including malaria, cancer, fibrosis, and inflammatory diseases.
Uses
Used in Pharmaceutical Industry:
rac-Febrifugine Dihydrochloride is used as a therapeutic agent for the treatment of [application reason] due to its medicinal properties.
Used in Antimalarial Applications:
rac-Febrifugine Dihydrochloride is used as an antimalarial agent for combating malaria, leveraging its therapeutic activity against the disease.
Used in Anticancer Applications:
In the field of oncology, rac-Febrifugine Dihydrochloride is used as a potential anticancer agent, targeting various types of cancer due to its bioactive properties.
Used in Anti-inflammatory Applications:
For inflammatory diseases, rac-Febrifugine Dihydrochloride is used as an anti-inflammatory agent to help reduce inflammation and alleviate symptoms.
Used in Antifibrotic Applications:
In cases of fibrosis, rac-Febrifugine Dihydrochloride is used as an antifibrotic agent to counteract the excessive formation of fibrous tissue and improve overall health.
Biochem/physiol Actions
Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 32434-42-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,4,3 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 32434-42:
(7*3)+(6*2)+(5*4)+(4*3)+(3*4)+(2*4)+(1*2)=87
87 % 10 = 7
So 32434-42-7 is a valid CAS Registry Number.
32434-42-7Relevant articles and documents
Stereoselective total synthesis of all the stereoisomers of (+)- and (?)-febrifugine and halofuginone
Perali, Ramu Sridhar,Bandi, Anjaneyulu
, (2020/07/04)
A convenient method for the total synthesis of all the stereoisomers of febrifugine and halofuginone using D-arabinose and L-arabinose as the key starting materials is reported. Apart from the inherent stereocenters in these pentose sugars, the method utilizes the selective hydrogenolysis of the anomeric O-benzyl group, stereoselective Grignard reaction and Wacker oxidation as the key steps to obtain the important precursors for the total synthesis.
