32461-83-9

Basic information

• Product Name: 2-Chloro-N-isobutyl-acetamide
• Synonyms: 2-Chloro-N-isobutyl-acetamide;acetamide, 2-chloro-N-(2-methylpropyl)-;2-chloro-N-isobutylacetamide(SALTDATA: FREE);2-chloro-N-(2-methylpropyl)acetamide;2-chloro-N-(2-methylpropyl)ethanamide
• CAS NO: 32461-83-9
• Molecular Formula: C₆H₁₂ClNO
• Molecular Weight: 149.62
• Mol File: 32461-83-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 259.9°Cat760mmHg
• Flash Point: 111°C
• Appearance: /
• Density: 1.029g/cm³
• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: 2-Chloro-N-isobutyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-isobutyl-acetamide(32461-83-9)
• EPA Substance Registry System: 2-Chloro-N-isobutyl-acetamide(32461-83-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 32461-83-9(Hazardous Substances Data)

Usage

General Description

2-Chloro-N-isobutyl-acetamide is a chemical compound with the molecular formula C6H12ClNO. It is an organic compound that contains a chloro group and an acetamide functional group. 2-Chloro-N-isobutyl-acetamide is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceutical products. 2-Chloro-N-isobutyl-acetamide has both medical and industrial applications and is used as a building block in the production of pharmaceuticals and other organic compounds. It is important to handle this chemical with care and follow proper safety protocols when working with it.

InChI:InChI=1/C6H12ClNO/c1-5(2)4-8-6(9)3-7/h5H,3-4H2,1-2H3,(H,8,9)

Upstream product

• 4960-82-1 dichlorodiacetamide 
• 78-81-9 isobutylamine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 18498-20-9 2-N-iso-butyl-2-oxoethyl phosphonium chloride 
• 5161-25-1 O,O-Dimethyl-S-(N-isobutyl-carbamoylmethyl)-phosphorodithioat 
• 62872-62-2 diethyl {2-(isobutylamino)-2-oxoethyl}phosphonate 
• 76810-33-8 C₁₃H₁₈N₂O₂ 
• 163629-04-7 1-(i-butylaminocarbonylmethyl)-2-methyl-indole 
• 163629-05-8 1-(i-butylaminocarbonylmethyl)-2-phenyl-indole 

Relevant articles and documents

Development of Quinazoline/Pyrimidine-2,4(1H,3H)-diones as Agonists of Cannabinoid Receptor Type 2

Starting from a prototypical structure 1, we describe our efforts to design and obtain novel quinazoline/pyrimidine-2,4(1H,3H)-diones with high CB2 agonist potency and selectivity as well as improved physicochemical characteristics, mainly hydrophilicity. The most potent and selective CB2 agonists, 8 and 36, in this series were also endowed with lower logP values than that of GW842166X and lead compound 1. These derivatives appear to be promising lead compounds for the development of future CB2 agonists.

Quinazoline dione derivatives and preparation method and application thereof

The invention provides novel quinazoline dione derivatives and a preparation method and application thereof. The compounds include compounds with the structure shown in the general formula V in the description and pharmaceutically acceptable salts or hydrates thereof. The compounds are active ligands of novel cannabinoid II receptors (CB2) and can be used for preparing medicine for treating, preventing and relieving CB2 receptor-mediated diseases, wherein the medicine is an agonist or partial agonist or inverse agonist or antagonist of CB2 receptors.

GLUCOSE UPTAKE INHIBITORS

Provided hererin are compounds that modulate glucose uptake activityand are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: Formula (I) wherein the variables have the values disclosed herein.