32464-55-4

Basic information

• Product Name: 2-(4,4-Diethoxybutyl)-1H-isoindole-1,3 (2H)-dione
• Synonyms: 2-(4,4-Diethoxybutyl)-1H-isoindole-1,3 (2H)-dione;1H-Isoindole-1,3(2H)-dione,2-(4,4-diethoxybutyl)-;2-(4,4-DIETHOXYBUTYL)ISOINDOLE-1,3-DIONE;2-(4,4-diethoxybutyl)isoindoline-1,3-dione
• CAS NO: 32464-55-4
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.34224
• Mol File: 32464-55-4.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4,4-Diethoxybutyl)-1H-isoindole-1,3 (2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4,4-Diethoxybutyl)-1H-isoindole-1,3 (2H)-dione(32464-55-4)
• EPA Substance Registry System: 2-(4,4-Diethoxybutyl)-1H-isoindole-1,3 (2H)-dione(32464-55-4)

Safety Data

• Hazardous Substances Data: 32464-55-4(Hazardous Substances Data)

Usage

General Description

2-(4,4-Diethoxybutyl)-1H-isoindole-1,3(2H)-dione, also known as diethoxybutyl phthalimide, is a chemical compound that belongs to the phthalimide class of chemicals. It is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and advanced materials. The diethoxybutyl substituent on the isoindole ring gives this compound unique properties that make it useful in a variety of chemical reactions. It is a white to off-white crystalline powder that is sparingly soluble in water but highly soluble in organic solvents. It is also known for its mild, non-offensive odor, making it easier to handle and work with in laboratory settings. Overall, 2-(4,4-Diethoxybutyl)-1H-isoindole-1,3(2H)-dione is a versatile and valuable chemical compound with a wide range of applications in the chemical industry.

Upstream product

• 85-44-9 phthalic anhydride 
• 6346-09-4 4-aminobutyrylaldehyde diethylacetal 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 138076-66-1 2-(4,4-diethoxybutylcarbamoyl)benzoic acid 

Downstream Products

• 223679-00-3 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester 
• 1026634-99-0 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 146548-65-4 [1-Amino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester 
• 113953-96-1 Boc->Cad<-Pua(Z)=Pht 
• 121903-75-1 Pht=Pua(Z)-OH 
• 3804-16-8 2-(7-chloro-1H-indol-3-yl)ethanamine 
• 2436-04-6 2-(7-methoxy-indol-3-yl)-ethylamine 
• 53157-46-3 N,N-phthalimido-2-(5-hydroxy-1H-indole-3-yl)ethylamine 
• 15741-71-6 N-phthalimidotryptamine 
• 1206830-87-6 C₂₄H₁₈N₂O₂ 
• 1265341-14-7 2-(4,4-difluorobutyl)isoindoline-1,3-dione 
• 1401067-58-0 2-(4-hydroxy-4-(2-nitrophenyl)butyl)isoindoline-1,3-dione 
• 1401067-72-8 2-(4-((tert-butyldimethylsilyl)oxy)-4-(2-nitrophenyl)butyl)-isoindoline-1,3-dione 
• 1621071-18-8 2-(4-hydroxy-4-(5-methyl-2-nitrophenyl)butyl)isoindoline-1,3-dione 

Relevant articles and documents

BIAMINOQUINOLINES AND NANOFORMULATIONS FOR CANCER TREATMENT

The present invention provides bisaminoquinoline compounds of Formula (I). The present invention also provides nanocarriers comprising compounds of the present invention, and methods of using the nanocarriers for treating diseases and imaging.

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties

CXCR4 is a seven-transmembrane receptor expressed by hematopoietic stem cells and progeny, as well as by ≥48 different cancers types. CXCL12, the only chemokine ligand of CXCR4, is secreted within the tumor microenvironment, providing sanctuary for CXCR4+ tumor cells from immune surveillance and chemotherapeutic elimination by (1) stimulating prosurvival signaling and (2) recruiting CXCR4+ immunosuppressive leukocytes. Additionally, distant CXCL12-rich niches attract and support CXCR4+ metastatic growths. Accordingly, CXCR4 antagonists can potentially obstruct CXCR4-mediated prosurvival signaling, recondition the CXCR4+ leukocyte infiltrate from immunosuppressive to immunoreactive, and inhibit CXCR4+ cancer cell metastasis. Current small molecule CXCR4 antagonists suffer from poor oral bioavailability and off-target liabilities. Herein, we report a series of novel tetrahydroisoquinoline-containing CXCR4 antagonists designed to improve intestinal absorption and off-target profiles. Structure-activity relationships regarding CXCR4 potency, intestinal permeability, metabolic stability, and cytochrome P450 inhibition are presented.

Compounds and methods for protease detection

Alternative methods for the detection and measurement of proteases in biological samples and compounds which allow for such detection are required to allow for rapid and selective identification of these enzymes. Compounds which allow for selective identification of these enzymes are provided with assays and kits for their use.