324748-62-1

Basic information

• Product Name: 1-Benzyl-3(R)isopropylpiperazine
• Synonyms: (S)-N4-BENZYL-2-ISOPROPYLPIPERAZINE;(S)-4-Benzyl-2-isopropylpiperazine;N4-BENZYL-2-ISOPROPYLPIPERAZINE;1-Benzyl-3(R)isopropylpiperazine;(S)-1-Benzyl-3-isopropylpiperazine;(R)-1-benzyl-3-isopropylpiperazine;(S)-1-Benzyl-3-isopropylpiperazine, 98+%;(3S)-3-(1-methylethyl)-1-(phenylmethyl)-Piperazine
• CAS NO: 324748-62-1
• Molecular Formula: C₁₄H₂₂N₂
• Molecular Weight: 218.34
• Product Categories: pharmacetical
• Mol File: 324748-62-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 309.596ºC at 760 mmHg
• Flash Point: 112.796ºC
• Appearance: /
• Density: 0.975g/cm3
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 1-Benzyl-3(R)isopropylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3(R)isopropylpiperazine(324748-62-1)
• EPA Substance Registry System: 1-Benzyl-3(R)isopropylpiperazine(324748-62-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 324748-62-1(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3(R)-isopropylpiperazine is a chemical compound that belongs to the class of piperazines. It is a psychoactive designer drug that is known to have stimulating and euphoric effects when consumed. 1-Benzyl-3(R)isopropylpiperazine is a derivative of piperazine and contains a benzyl group and an isopropyl group attached to the piperazine ring. It has been identified as a potential drug of abuse and is not approved for medical use. The chemical structure of 1-Benzyl-3(R)-isopropylpiperazine suggests that it may act on the central nervous system, leading to altered states of consciousness and potential risks to human health. As such, it is important to be aware of the potential dangers associated with this chemical and to avoid its recreational use.

InChI:InChI=1/C14H22N2/c1-12(2)14-11-16(9-8-15-14)10-13-6-4-3-5-7-13/h3-7,12,14-15H,8-11H2,1-2H3

Upstream product

• 13734-41-3 t-Boc-L-valine 
• 100-46-9 benzylamine 
• 220663-44-5 (S)-1-benzyl-3-isopropylpiperazine-2,5-dione 
• 4070-48-8 L-Valine methyl ester 
• 1492-06-4 methyl (S)-2-(2-chloroacetylamino)-2,3-dimethylbutanoate 

Downstream Products

• 84468-53-1 (S)-2-isopropylpiperazine 
• 1007112-70-0 (S)-methyl 2-(4-benzyl-2-isopropylpiperazin-1-yl)benzoxazole-4-carboxylate 
• 674791-99-2 (S)-tert-butyl 2-isopropyl-4-benzylpiperazine-1-carboxylate 

Relevant articles and documents

Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity

Neuropeptide S modulates important neurobiological functions including locomotion, anxiety, and drug abuse through interaction with its G protein-coupled receptor known as neuropeptide S receptor (NPSR). NPSR antagonists are potentially useful for the treatment of substance abuse disorders against which there is an urgent need for new effective therapeutic approaches. Potent NPSR antagonists in vitro have been discovered which, however, require further optimization of their in vivo pharmacological profile. This work describes a new series of NPSR antagonists of the oxazolo[3,4-a]pyrazine class. The guanidine derivative 16 exhibited nanomolar activity in vitro and 5-fold improved potency in vivo compared to SHA-68, a reference pharmacological tool in this field. Compound 16 can be considered a new tool for research studies on the translational potential of the NPSergic system. An in-depth molecular modeling investigation was also performed to gain new insights into the observed structure-activity relationships and provide an updated model of ligand/NPSR interactions.

PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES

The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.Formula (I)

Piperazine derivative

A piperazine compound represented by formula (1): wherein X is —CH2—, —C(O)— or —CH(CH3)—; R1is a hydrogen atom or alkyl group; and R2is a hydrogen atom, alkyl group, hydroxyalkyl group, arylalkyl group, heteroarylalkyl group, carboxyalkyl group, carboxamidoalkyl group, aminoalkyl group or guanidinoalkyl group; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.