324752-72-9

Basic information

• Product Name: Carbamic acid, [(1R,2S)-2-hydroxy-1-methyl-4-pentenyl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [(1R,2S)-2-hydroxy-1-methyl-4-pentenyl]-, 1,1-dimethylethyl
• CAS NO: 324752-72-9
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.28934
• Product Categories: N-BOC
• Mol File: 324752-72-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1R,2S)-2-hydroxy-1-methyl-4-pentenyl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R,2S)-2-hydroxy-1-methyl-4-pentenyl]-, 1,1-dimethylethyl(324752-72-9)
• EPA Substance Registry System: Carbamic acid, [(1R,2S)-2-hydroxy-1-methyl-4-pentenyl]-, 1,1-dimethylethyl(324752-72-9)

Safety Data

• Hazardous Substances Data: 324752-72-9(Hazardous Substances Data)

Upstream product

• 174787-76-9 (4R,5R)-5-allyl-3-tert-butoxycarbonyl-4-methyl-2-oxazolidinone 
• 82353-56-8 (2R)-2-N-t-butoxycarbonyl-aminopropanal 
• 762-72-1 allyl-trimethyl-silane 
• 115269-78-8 (4R,5R)-5-allyl-4-methoxy-2-oxazolidinone 
• 174851-37-7 (4R,5R)-5-allyl-4-methyl-2-oxazolidinone 
• 79069-50-4 Boc-Ala-H 
• 106-95-6 allyl bromide 
• 107-37-9 allyltrichlorosilane 
• 1730-25-2 allylmagnesium bromide 
• 1294446-91-5 (S)-tert-butyl-N-(3-oxohex-5-en-2-yl)carbamate 
• 15761-38-3 L-N-Boc-Ala 
• 146553-06-2 tert-butyl {(S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 85116-38-7 (-)-B-allyldiisopinocampheylborane 

Relevant articles and documents

A simple one pot procedure for the generation of homoallylic alcohols from acetals and amino acids

Treatment of acetals (1 and 2) and amino acetals (3-5) with either trifluoroacetic acid (TFA) or silica gel followed by tetraallyltin gave excellent yields of the corresponding homoallylic alcohols (68 - 100%).

PYRIMIDINE CARBOXAMIDES AS GSK-3 INHIBITORS

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.

Exploring Leishmania major Inositol Phosphorylceramide Synthase (LmjIPCS): Insights into the ceramide binding domain

The synthesis of set of ceramide analogues exploring hydrophobicity in the acyl chains and the degree and nature of hydroxylation is described. These have been assayed against the parasitic protozoan enzyme LmjIPCS. These studies showed that whilst the C-3 hydroxyl group was not essential for turnover it provided enhanced affinity. Reflecting the membrane bound nature of the enzyme a long (C13) hydrocarbon ceramide tail was necessary for both high affinity and turnover. Whilst the N-acyl chain also contributed to affinity, analogues lacking the amide linkage functioned as competitive inhibitors in both enzyme and cell-based assays. A model that accounts for this observation is proposed.