324761-30-0

Basic information

• Product Name: C₃₆H₃₈ClN₃O₃
• Synonyms: C₃₆H₃₈ClN₃O₃
• CAS NO: 324761-30-0
• Molecular Weight: 596.169
• Mol File: 324761-30-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₆H₃₈ClN₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₃₈ClN₃O₃(324761-30-0)
• EPA Substance Registry System: C₃₆H₃₈ClN₃O₃(324761-30-0)

Safety Data

• Hazardous Substances Data: 324761-30-0(Hazardous Substances Data)

Upstream product

• 62121-84-0 endoperoxide of 1,4-diphenylcyclopentadiene 
• 4982-34-7 1,4-diphenyl-1,3-cyclopentadiene 
• 86-98-6 4,7-dichloroquinoline 
• 53186-45-1 N₁-(7-chloroquinolin-4-yl)butane-1,4-diamine 
• 324519-73-5 C₂₃H₂₂O₄ 

Relevant articles and documents

Synthesis and Antimalarial Activity of Trioxaquine Derivatives

Trioxaquines are dual molecules that contain a trioxane motif linked to an aminoquinoline entity. Among the different compounds of this series, trioxaquine cis-15 (DU1302c), prepared from α-terpinene, a cheap natural product, showed efficient antimalarial activity in vitro on both sensitive and resistant strains of Plasmodium falciparum (IC50 = 5-19 nM). A stereochemical description of this stable, nontoxic, and non-genotoxic antimalarial agent is detailed. Mice infected with P. vinckei were successfully treated with cis-15 in a four-day suppressive test. The doses required to decrease parasitemia by 50% (ED50) were 5 and 18 mg kg -1d-1 after intraperitoneal and oral administration, respectively. Parasitemia clearance was complete without recrudescence at an intraperitoneal dose of 20 mgkg-1d-1.