324763-44-2Relevant articles and documents
Process for the preparation of aryloctanoyl amides
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Page 10, (2010/01/31)
Compounds of formula IwhereinR1is for example 3-methoxyprop-3-yloxy, R2is for example methoxy, R3and R4are in each case for example isopropyl, and R5is H2NC(O)-[C(CH3)2]-CH2-, are obtainable by reaction of compounds of formula IV(IV) with a metal organic derivative of 1-(3-R1-4-R2-phen-1-yl)-2-R3-3-halogen propanes to form a compound of formula VI,followed by removal of the pseudoephedrine protecting group and the OH group, reaction of the resulting lactone with an amine R5-NH2and removal of protecting group Z.
A convergent synthesis of the renin inhibitor CGP60536B
Sandham,Taylor,Carey,Fassler
, p. 10091 - 10094 (2007/10/03)
Pseudoephedrine serves as a dual purpose chiral auxiliary and protecting group in the synthesis of the novel orally active renin inhibitor CGP60536B. (C) 2000 Elsevier Science Ltd.