324788-99-0

Basic information

• Product Name: 5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one
• Synonyms: 5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one
• CAS NO: 324788-99-0
• Molecular Weight: 311.31
• Mol File: 324788-99-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one(324788-99-0)
• EPA Substance Registry System: 5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one(324788-99-0)

Safety Data

• Hazardous Substances Data: 324788-99-0(Hazardous Substances Data)

Upstream product

• 403-23-6 2-fluoro-4-nitrobenzoyl chloride 
• 403-24-7 2-fluoro-4-nitrobenzoic acid 
• 1427-07-2 2-fluoro-4-nitrotoluene 
• 60456-26-0 (R)-glycidyl butyrate 
• 324788-98-9 tert-butyl 4-benzyloxycarbonylamino-2-fluoro-benzoate 
• 157665-46-8 tert-butyl 2-fluoro-4-nitrobenzoate 
• 140373-77-9 tert-butyl 2-fluoro-4-aminobenzoate 

Downstream Products

• 1087352-59-7 tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate 
• 1087352-87-1 methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate 
• 1087353-05-6 O-methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thiocarbamate 
• 1087353-76-1 tert-butyl {3-[4-(4-chloromethyl-thiazol-2-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate 
• 1087352-62-2 N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-acetamide 
• 1087353-14-7 N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide 
• 1087353-74-9 tert-butyl [3-(4-carbamoyl-3-fluoro-phenyl)-2-oxo-oxazolidin-5(S)-ylmethyl]-carbamate 
• 1087353-75-0 tert-butyl [3-(3-fluoro-4-thiocarbamoyl-phenyI)-2-oxo-oxazolidin-5(S)-ylmethyl]-carbamate 
• 324789-26-6 4-(5-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-benzamide 
• 324789-28-8 5-(S)-aminomethyl-3-[4'-aminocarbonyl-3'-fluorophenyl]oxazolidine-2-one 
• 324789-22-2 4-(5(R)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoic acid 
• 232950-93-5 5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one 
• 232951-33-6 5-(S)-(N-Acetylaminomethyl)-3-[4'-(tert-butoxy)carbonyl-3'-fluorophenyl]-oxazolidine-2-one 
• 232950-92-4 5-(S)-Acetamidomethyl-3-[4'-carboxy-3'-fluorophenyl]-oxazolidine-2-one 

Relevant articles and documents

NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS

The present invention relates to novel oxazolidinone compounds of formula (I) with antibacterial activity, their pharmaceutically acceptable salts, their stereoisomers, their prodrugs, pharmaceutical compositions comprising the same and to their use as therapeutic agents

Oxazolidinone combinatorial libraries, compositions and methods of preparation

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.