32480-08-3

Basic information

• Product Name: 3,7,11-Trimethyl-(E)-6,10-dodecadienal
• Synonyms: 3,7,11-Trimethyl-(E)-6,10-dodecadienal
• CAS NO: 32480-08-3
• Molecular Formula: C15H26O
• Molecular Weight: 222.36634
• Mol File: 32480-08-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,7,11-Trimethyl-(E)-6,10-dodecadienal(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7,11-Trimethyl-(E)-6,10-dodecadienal(32480-08-3)
• EPA Substance Registry System: 3,7,11-Trimethyl-(E)-6,10-dodecadienal(32480-08-3)

Safety Data

• Hazardous Substances Data: 32480-08-3(Hazardous Substances Data)

Usage

General Description

3,7,11-Trimethyl-(E)-6,10-dodecadienal, also known as tridecadienal, is a chemical compound found in various plants and foods, including tomatoes, bananas, and coffee. It is known for its green, floral, and fruity aroma, and is commonly used as a flavoring agent in the food and beverage industry. Tridecadienal is also a pheromone component in certain insects, serving as a chemical signal for mating and communication. Additionally, it has been studied for its potential use as a natural pesticide due to its insecticidal properties. Overall, 3,7,11-Trimethyl-(E)-6,10-dodecadienal is a versatile compound with applications in food flavoring, insect communication, and pest control.

Upstream product

• 106-28-5 Farnesol 
• 19317-11-4 farnesal 

Relevant articles and documents

Inactivation of protein farnesyltransferase by active-site-targeted dicarbonyl compounds

Upon farnesylation by protein farnesyltransferase (FTase), key proteins become compartmentalized in cells. For example, cell membrane localization is essential for the mitogenic role of mutant Ras protein, which acts as a switch for cancer cell proliferation. We report that α-dicarbonyl compounds derived from the isoprenoid skeleton or other hydrophobic groups potently obstruct farnesylation of a Ras model peptide by human recombinant FTase in vitro. A geranyl-derived isoprenoid diketone, 5,9-dimethyl-8-decene-2,3-dione, at 17 μM caused a 62% reduction in FTase activity after 30 minutes. A farnesyl-derived isoprenoid diketone, 5,9,13-trimethyl-8,12-tetradecadiene-2,3-dione, at 93 μM caused a 94% reduction after 30 minutes. Other dicarbonyl compounds found to be effective against FTase in vitro were (±)-6-(camphorquinone-10-sulfonamido)-hexanoic acid, 4,4′-biphenyldiglyoxaldehyde, dehydroascorbic acid 6-palmitate, 2-oxododecanal, and phenylglyoxal. Higher concentrations of the α-dicarbonyl compound resulted in more rapid and more extensive inactivation. These findings demonstrate that α-dicarbonyl compounds targeted to FTase interfere with protein farnesylation in vitro and may lead to derivatives that have utility as chemotherapeutic agents.