3249-01-2

Basic information

• Product Name: Z-Gly-L-Tyr-OEt
• Synonyms: N-(Benzyloxycarbonyl)-Gly-L-Tyr-OEt;N-Cbz-Gly-L-Tyr-OEt;Z-Gly-L-Tyr-OEt
• CAS NO: 3249-01-2
• Molecular Formula: C₂₁H₂₄N₂O₆
• Molecular Weight: 400.4251
• Mol File: 3249-01-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 653.5°Cat760mmHg
• Flash Point: 349°C
• Appearance: /
• Density: 1.255g/cm³
• Vapor Pressure: 1.11E-17mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: Z-Gly-L-Tyr-OEt(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Gly-L-Tyr-OEt(3249-01-2)
• EPA Substance Registry System: Z-Gly-L-Tyr-OEt(3249-01-2)

Safety Data

• Hazardous Substances Data: 3249-01-2(Hazardous Substances Data)

Usage

General Description

Z-Gly-L-Tyr-OEt is a chemical compound that consists of three amino acids - glycine, tyrosine, and ethyl ester. The compound is used in biochemical research and pharmaceutical applications due to its ability to mimic natural peptides. Z-Gly-L-Tyr-OEt is often utilized as a model for studying the effects of peptide interactions in biological systems. Its structure incorporates a blocking group, Z, which confers stability and prevents degradation in the body. Z-Gly-L-Tyr-OEt has shown promising potential for targeting specific receptors and enzymes in drug development and can offer valuable insights into the design of novel therapeutic agents.

InChI:InChI=1/C21H24N2O6/c1-2-28-20(26)18(12-15-8-10-17(24)11-9-15)23-19(25)13-22-21(27)29-14-16-6-4-3-5-7-16/h3-11,18,24H,2,12-14H2,1H3,(H,22,27)(H,23,25)

Upstream product

• 15050-24-5 N-(benzyloxycarbonyl)glycyl chloride 
• 949-67-7 L-tyrosine ethyl ester 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 4024-42-4 1-(N-benzyloxycarbonyl-glycyloxy)-piperidine 
• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 80681-01-2 [2-Oxo-2-(2-thioxo-thiazolidin-3-yl)-ethyl]-carbamic acid benzyl ester 
• 77374-26-6 C₂₁H₂₅BN₂O₇ 
• 1738-86-9 Z-Gly-ONp 
• 3065-02-9 C₂₃H₂₀N₂O₄ 
• 87023-85-6 1-(Cbz-glycyl)-3,5-dimethylpyrazole 
• 76410-58-7 p-borono-L-phenylalanine 
• 77374-24-4 C₁₁H₁₆BNO₄*ClH 
• 64-17-5 ethanol 
• 19790-44-4 Cbz-Gly-Tyr-NH₂ 

Downstream Products

• 7801-35-6 Cbz-G-Y-OH 
• 53823-17-9 N-(N-benzyloxycarbonyl-glycyl)-L-tyrosine hydrazide 
• 19240-28-9 N-glycyl-L-tyrosine ethyl ester 
• 19790-44-4 Cbz-Gly-Tyr-NH₂ 
• 3561-36-2 N-[N-(N-benzyloxycarbonyl-glycyl)-L-tyrosyl]-glycine ethyl ester 
• 658-79-7 N-Gly-Tyr 

Relevant articles and documents

One-step C-terminal deprotection and activation of peptides with peptide amidase from stenotrophomonas maltophilia in neat organic solvent

Chemoenzymatic peptide synthesis is a rapidly developing technology for cost effective peptide production on a large scale. As an alternative to the traditional C→N strategy, which employs expensive N-protected building blocks in each step, we have investigated an N→C extension route that is based on activation of a peptide C-terminal amide protecting group to the corresponding methyl ester. We found that this conversion is efficiently catalysed by Stenotrophomonas maltophilia peptide amidase in neat organic media. The system excludes the possibility of internal peptide cleavage as the enzyme lacks intrinsic protease activity. The produced peptide methyl ester was used for peptide chain extension in a kinetically controlled reaction by a thermostable protease.

PLURIPOTENTIAL AMINO ACIDS I. (L)-p-DIHYDROXYBORYLPHENYLALANINE (L-Bph) AS A PRECURSOR OF L-Phe AND L-Tyr CONTAINING PEPTIDES; SPECIFIC TRITIATION OF L-Phe-CONTAINING PEPTIDES AT A FINAL STEP IN THE SYNTHESIS

p-Dihydroxyborylphenylalanine has been resolved and incorporated into simple di and tripeptides; treatment of these with hydrogen peroxide or diammino silver salts results respectively in formation of tyrosine and phenylalanine peptides.

Amino-acids and peptides. XXIV. The use of esters of 1-hydroxypiperidine and of other NN-dialkylhydroxylamines in peptide synthesis and as selective acylating agents.

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