32520-55-1

Basic information

• Product Name: 6-METHOXYKAEMPFEROL
• Synonyms: 6-METHOXYKAEMPFEROL;3,4',5,7-Tetrahydroxy-6-methoxyflavone;Kaempferol 6-methyl ether
• CAS NO: 32520-55-1
• Molecular Formula: C₁₆H₁₂O₇
• Molecular Weight: 316.26
• Product Categories: Miscellaneous Natural Products
• Mol File: 32520-55-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-METHOXYKAEMPFEROL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXYKAEMPFEROL(32520-55-1)
• EPA Substance Registry System: 6-METHOXYKAEMPFEROL(32520-55-1)

Safety Data

• Hazardous Substances Data: 32520-55-1(Hazardous Substances Data)

Usage

General Description

6-Methoxykaempferol is a natural flavonoid compound that belongs to the class of flavonols. It is commonly found in various plant sources, including fruits, vegetables, and medicinal herbs. 6-METHOXYKAEMPFEROL has been studied for its potential health benefits, including antioxidant, anti-inflammatory, and anticancer properties. 6-Methoxykaempferol has also been investigated for its potential to support cardiovascular health and improve glucose metabolism. Overall, 6-Methoxykaempferol shows promise as a natural compound with potential therapeutic applications in various health conditions.

Upstream product

• 188927-58-4 7-Benzyloxy-2-(4-benzyloxy-phenyl)-3,5-dihydroxy-6-methoxy-chromen-4-one 
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• 3162-51-4 1-(2,4-Bis-benzyloxy-3,6-dimethoxy-phenyl)-ethanone 
• 3162-52-5 1-(4-benzyloxy-2-hydroxy-3,6-dimethoxy-phenyl)-ethanone 
• 7499-99-2 1-(2,4-dihydroxy-3,6-dimethoxy)phenylethanone 
• 188927-31-3 4-benzyloxy-6-hydroxy-3-methoxy-2-isopropoxyacetophenone 
• 188927-62-0 1-(4-Benzyloxy-2-isopropoxy-3,6-dimethoxy-phenyl)-ethanone 
• 188927-48-2 7-Benzyloxy-2-(4-benzyloxy-phenyl)-5-isopropoxy-6-methoxy-chromen-4-one 
• 188927-38-0 7-Benzyloxy-2-(4-benzyloxy-phenyl)-3-hydroxy-5-isopropoxy-6-methoxy-chromen-4-one 
• 188927-33-5 1-(4-Benzyloxy-6-hydroxy-2-isopropoxy-3-methoxy-phenyl)-3-(4-benzyloxy-phenyl)-propane-1,3-dione 
• 1026154-00-6 4-Benzyloxy-benzoic acid 2-acetyl-5-benzyloxy-3-isopropoxy-4-methoxy-phenyl ester 
• 188927-43-7 Toluene-4-sulfonic acid 7-benzyloxy-2-(4-benzyloxy-phenyl)-5-hydroxy-6-methoxy-4-oxo-4H-chromen-3-yl ester 
• 188927-53-9 Toluene-4-sulfonic acid 7-benzyloxy-2-(4-benzyloxy-phenyl)-5-isopropoxy-6-methoxy-4-oxo-4H-chromen-3-yl ester 

Downstream Products

• 32557-95-2 3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-6-methoxy-chromen-4-one 

Relevant articles and documents

Studies of the selective O-alkylation and dealkylation of flavonoids. XXII. A convenient method for synthesizing 3,5,7-trihydroxy-6-methoxyflavones

The demethylation of 3,4-dioxygenated 6-methoxy-2- isopropoxyacetophenones was studied and it was found that 4-benzyloxy-6- hydroxy-3-methoxy-2-isopropoxyacetophenone was easily obtained from 4- benzyloxy-3,6-dimethoxy-2-isopropoxyacetophenone by selective demethylation with anhydrous aluminum bromide-sodium iodide in acetonitrile. The acetophenone was converted into 7-benzyloxy-3-hydroxy-6-methoxy-5- isopropoxyflavones by cyclization followed by oxidation with dimethyldioxirane. The isopropoxy group in the flavones was selectively cleaved with anhydrous aluminum chloride via the corresponding tosylates to give 7-benzyloxy-3,5-dihydroxy-6-methoxyflavones, which were converted into the desired 3,5,7-trihydroxy-6-methoxyflavones by hydrogenolysis. The process was suitable as a general method for synthesizing 3,5,7-trihydroxy-6- methoxyflavones and five flavones were synthesized. We also examined the 13C-NMR spectra of twelve kinds of 3,5,6,7-tetraoxygenated 4'- methoxyflavones and revised the proposed structure of a natural flavone.