325464-21-9Relevant articles and documents
Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites
Marquez,Wang,Nicklaus,Maier,Manoharan,Christman,Banavali,Mackerell A.D.
, p. 451 - 459 (2001)
Pseudorotationally locked sugar analogues based on bicyclo[3.1.0]-hexane templates were placed in DNA duplexes as abasic target sites in the M.HhaI recognition sequence. The binding affinity of the enzyme increases when the abasic site is constrained to t