32596-43-3

Basic information

• Product Name: 2,6-DIFORMYL-4-CHLOROPHENOL
• Synonyms: TIMTEC-BB SBB003721;2,6-DIFORMYL-4-CHLOROPHENOL;AKOS BC-1723;5-CHLORO-2-HYDROXYISOPHTHALALDEHYDE;5-CHLORO-2-HYDROXY-1,3-BENZENEDICARBOXALDEHYDE;2,6-DIFORMYL-4-CHLOROPHENOL 99%;2-Hydroxy-5-chloroisophthalaldehyde;2,6-Diformyl-4-chlorophenol,99%
• CAS NO: 32596-43-3
• Molecular Formula: C₈H₅ClO₃
• Molecular Weight: 184.58
• EINECS: 251-123-3
• Mol File: 32596-43-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 119-125 °C
• Boiling Point: 246.1 °C at 760 mmHg
• Flash Point: 102.6 °C
• Appearance: /
• Density: 1.3964 (estimate)
• Vapor Pressure: 0.0177mmHg at 25°C
• Refractive Index: 1.679
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.95±0.23(Predicted)
• CAS DataBase Reference: 2,6-DIFORMYL-4-CHLOROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIFORMYL-4-CHLOROPHENOL(32596-43-3)
• EPA Substance Registry System: 2,6-DIFORMYL-4-CHLOROPHENOL(32596-43-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Hazardous Substances Data: 32596-43-3(Hazardous Substances Data)

Usage

Chemical Properties

pale yellow to yellow-brownish crystalline powder

InChI:InChI=1/C8H5ClO3/c9-7-1-5(3-10)8(12)6(2-7)4-11/h1-4,12H

Upstream product

• 17026-49-2 4-chloro-2,6-bis(hydroxymethyl)phenol 
• 50-00-0 formaldehyd 
• 106-48-9 4-chloro-phenol 
• 111171-18-7 5-chloro-2-hydroxy-3-(hydroxymethyl)benzaldehyde 
• 1123-63-3 2,6-dimethyl-4-chlorophenol 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 131467-81-7 4-chloro-2-formyl-6-(4-methyl-2-oxo-5,8-diazanona-3,8-dienyl)phenol 
• 131467-83-9 4-chloro-2,6-bis-(4-methyl-2-oxo-5,8-diazanona-3,8-dienyl)phenol 
• 98299-14-0 5-chloro-2-methoxy-1,3-benzene dicarboxaldehyde 
• 158629-89-1 2-{[5-Chloro-3-(1-hydroxy-2-methoxycarbonyl-allyl)-2-methoxy-phenyl]-hydroxy-methyl}-acrylic acid methyl ester 
• 158629-93-7 2-{Acetoxy-[3-(1-acetoxy-2-methoxycarbonyl-allyl)-5-chloro-2-methoxy-phenyl]-methyl}-acrylic acid methyl ester 
• 164979-01-5 5-chloro-2-(8-phenyloctyloxy)-3-benzenedicarboxaldehyde 
• 206561-14-0 UO₂((CH₂)2(NCHC₆H₂Cl(O)CHO)(NCHC₆H₂Cl(OH)CH(OH)OCH₃))(NO₃) 
• 178912-53-3 Gd⁽³⁺⁾*N(CH₂CH₂NCHC₆H₂(O)Cl(CHO))3^(3-)=Gd(N(CH₂CH₂NCHC₆H₂(O)Cl(CHO))3) 

Relevant articles and documents

An improved oxidation approach for preparing 4-substituted-2,6- diformylphenol by manganese(IV) dioxide

The method for the oxidation of 4-alkyl-2,6-di(hydroxymethyl)phenol to 4-alkyl-2,6-diformylphenol (alkyl = Me or t-Bu) by activated manganese(IV) dioxide was improved, and also expanded to the oxidation of 4-chloro-2,6- di(hydroxymethyl)phenol. The resulting three dialdehydes were obtained in good yields.

Readily prepared inclusion forming chiral calixsalens

Calixsalens, chiral triangular hexaimines are readily synthesized by [3 + 3] cyclocondensation of trans-(R,R)-1,2-diaminocyclohexane with 2-hydroxyisophthalaldehyde derivatives. The usually rigid calixsalen ring is able to invert its conformation as a consequence of steric repulsion between bulky substituents at the C5 positions of the aromatic rings. The steric and electronic nature of the substituents does not affect only the conformation of the macrocycle. Small polar substituents enforce dimeric self-association to form an apohost where each of the monomers simultaneously serves as the host and the guest of its partner. Non-associating calixsalens form assemblies in which two symmetry-related molecules are arranged in a head-to-head fashion to form a capsule, or unimolecular cages that are able to entrap solvent molecules in their intrinsic voids.

Substituted benzopyran analogs for the treatment of inflammation

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.