32599-03-4

Basic information

• Product Name: 1-(3-phenoxypropyl)piperidine
• Synonyms: 1-(3-phenoxypropyl)piperidine
• CAS NO: 32599-03-4
• Molecular Weight: 219.327
• Mol File: 32599-03-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-phenoxypropyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-phenoxypropyl)piperidine(32599-03-4)
• EPA Substance Registry System: 1-(3-phenoxypropyl)piperidine(32599-03-4)

Safety Data

• Hazardous Substances Data: 32599-03-4(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 3384-04-1 3-chloropropyl phenyl ether 
• 5472-49-1 1-(3-chloropropyl)piperidine hydrochloride 
• 108-95-2 phenol 
• 588-63-6 3-phenoxypropyl bromide 
• 20549-68-2 1-(3-iodopropoxy)benzene 

Downstream Products

• 588-63-6 3-phenoxypropyl bromide 

Relevant articles and documents

Kojic acid derivatives as histamine H3 receptor ligands

The histamine H3 receptor (H3R) is a promising target in the development of new compounds for the treatment of mainly centrally occurring diseases. However, emerging novel therapeutic concepts have been introduced and some indications in the H3R field, e.g. migraine, pain or allergic rhinitis, might take advantage of peripherally acting ligands. In this work, kojic acid-derived structural elements were inserted into a well established H3R antagonist/inverse agonist scaffold to investigate the bioisosteric potential of γ-pyranones with respect to the different moieties of the H3R pharmacophore. The most affine compounds showed receptor binding in the low nanomolar concentration range. Evaluation and comparison of kojic acid-containing ligands and their corresponding phenyl analogues (3-7) revealed that the newly integrated scaffold greatly influences chemical properties (S Log P, topological polar surface area (tPSA)) and hence, potentially modifies the pharmacokinetic profile of the different derivatives. Benzyl-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)methanamine ligands 3 and 4 belong to the centrally acting diamine-based class of H3R antagonist/inverse agonist, whereas kojic acid analogues 6 and 7 might act peripherally. The latter compounds state promising lead structures in the development of H3R ligands with a modified profile of action.

Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists

The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.