326-66-9

Basic information

• Product Name: 4'-Bromo-2'-fluoroacetanilide
• Synonyms: N-(4-BROMO-2-FLUOROPHENYL)ACETAMIDE;TIMTEC-BB SBB009911;4'-BROMO-2'-FLUOROACETANILIDE;4-BROMO-2-FLUOROACETANILIDE;4-Bromo-2-Fluoroacetaniline;4'-Bromo-2'-fluoroacetanilide, 99+%;4-Bromo-2-fluorophenylacetamide;4'-Bromo-2'-fluoroacetanilide 98%
• CAS NO: 326-66-9
• Molecular Formula: C₈H₇BrFNO
• Molecular Weight: 232.05
• EINECS: 206-314-6
• Product Categories: Fluorobenzene;Benzenes;Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds;Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 326-66-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 148-151 °C
• Boiling Point: 332.9 °C at 760 mmHg
• Flash Point: 155.1 °C
• Appearance: Light beige amorphous powder
• Density: 1.5813 (estimate)
• Vapor Pressure: 0.0686mmHg at 25°C
• Refractive Index: 1.423
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.16±0.70(Predicted)
• BRN: 3250459
• CAS DataBase Reference: 4'-Bromo-2'-fluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Bromo-2'-fluoroacetanilide(326-66-9)
• EPA Substance Registry System: 4'-Bromo-2'-fluoroacetanilide(326-66-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22
• Safety Statements: 45-28A
• RIDADR: 2811
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 326-66-9(Hazardous Substances Data)

Usage

Chemical Properties

LIGHT BEIGE AMORPHOUS POWDER

InChI:InChI=1/C8H5F3O3/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2

Upstream product

• 399-31-5 N-(2-fluorophenyl)acetamide 
• 389-32-2 acetic acid-(N-bromo-2-fluoro-anilide) 
• 108-90-7 chlorobenzene 
• 76-03-9 trichloroacetic acid 
• 103-88-8 4-bromoacetanilide 
• 367-24-8 4-bromo-2-fluoroaniline 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 97760-94-6 N-(2-fluoro-4-iodo-phenyl)-acetamide 
• 93129-68-1 4-acetylamino-3-fluoro-benzonitrile 
• 269410-27-7 N-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide 
• 305800-64-0 N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluoro-phenyl]-acetamide 
• 713-11-1 4-acetamido-3-fluorobenzoic acid 
• 399-31-5 N-(2-fluorophenyl)acetamide 
• 1519051-08-1 N'-(4-bromo-2-fluorophenyl)-N-phenylacetimidamide 

Relevant articles and documents

A para-C–H Functionalization of Aniline Derivatives via In situ Generated Bulky Hypervalent Iodinium Reagents

A practical para-C-H functionalization of aniline derivatives has been developed using an in situ generated bulky hypervalent iodinium reagent. Para-iodo, bromo, chloro, nitro, trifluormethyl aniline derivatives can be obtained efficiently, in many cases in 10 min in a transition metal-free manner. Medicinal chemicals or intermediates can be purified without column chromatography or recrystallization, which significantly reduces the waste and simplifies the work-up process.

NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.