3260-51-3Relevant articles and documents
Photodegradation of antimycotic drugs. 4. Communication: Photodegradation of flucytosine and griseofulvin
Thoma,Kuebler,Reimann
, p. 455 - 463 (2007/10/03)
The antimycotic drug substances flucytosine and griseofulvin are degraded under the influence of light. A liquid chromatography-mass spectrometry system helped us to elucidate some of the photodegradation pathways. 5-Fluorouracil is one of the photodegradation products of flucytosine in aqueous solution. The photodegradation of griseofulvin in solutions is mainly influenced by the solvent. The photodegradation product deschlorgriseofulvin could be detected in aqueous solution as well as in ethanolic and methanolic solution. Two photodegradation products found in ethanolic solution could, however, not be detected in methanolic or aqueous solution. Storage instructions of the pharmocopoeias are quite surprising. The US and the German pharmacopoeia recommend light protected storage for flucytosine but not for griseofulvin although griseofulvin is photodegraded more rapidly than flucytosine.