326008-99-5Relevant articles and documents
A practical synthesis of the PDE4 inhibitor, SB-207499, from a cyclohexanone precursor
Badham, Neil F.,Chen, Jian-Hao,Cummings, Paul G.,Dell'Orco, Philip C.,Diederich, Ann M.,Eldridge, Ann M.,Mendelson, Wilford L.,Mills, Robert J.,Novack, Vance J.,Olsen, Mark A.,Rustum, Abu M.,Webb, Kevin S.,Yang, Shawn
, p. 101 - 108 (2003)
The synthesis of SB-207499 is described. Investigation and development of new strategies for the homologation of ketone, 4-cyano-4-[3-(cyclopentyloxy)-4-(methoxyphenyl)]-cyclohexan-1-one 2 are described which produce SB-207499. Our ultimate route of synthesis to SB-207499 is robust and operationally simple and produces the final drug substance in good yield and purity.
