32604-86-7 Usage
Description
Monoacetyldapsone hydroxylamine, also known as 4''-(N-Hydroxysulfanilyl)acetanilide, is an intermediate compound in the synthesis of Aceyl Dapsone (A168435), which is a metabolite of Dapsone (D193250). Dapsone is an antibacterial agent commonly used in the treatment of dermatitis herpetiformis. Monoacetyldapsone hydroxylamine plays a crucial role in the pharmaceutical industry due to its involvement in the synthesis of these important drugs.
Uses
Used in Pharmaceutical Industry:
Monoacetyldapsone hydroxylamine is used as an intermediate in the synthesis of Aceyl Dapsone (A168435) for its role in producing Dapsone (D193250), an antibacterial agent. The application reason is that Dapsone is effective in treating dermatitis herpetiformis, a skin condition characterized by a group of skin lesions known as papules and vesicles.
Additionally, since Dapsone has a wide range of applications in treating various bacterial infections, monoacetyldapsone hydroxylamine indirectly contributes to the development and production of medications that target these infections. Its importance lies in its position as a key component in the synthesis process of a drug with significant therapeutic value.
Check Digit Verification of cas no
The CAS Registry Mumber 32604-86-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,6,0 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 32604-86:
(7*3)+(6*2)+(5*6)+(4*0)+(3*4)+(2*8)+(1*6)=97
97 % 10 = 7
So 32604-86-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H14N2O4S/c1-10(17)15-11-2-6-13(7-3-11)21(19,20)14-8-4-12(16-18)5-9-14/h2-9,16,18H,1H3,(H,15,17)
32604-86-7Relevant articles and documents
Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes
Vyas, Piyush M.,Roychowdhury, Sanjoy,Woster, Patrick M.,Svensson, Craig K.
, p. 275 - 286 (2007/10/03)
Cutaneous drug reactions (CDR) are responsible for numerous minor to life-threatening complications. Though the exact mechanism for CDR is not completely understood, evidence suggests that bioactivation of drugs to reactive oxygen or nitrogen species is a
