326488-07-7

Basic information

• Product Name: 1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-ol
• Synonyms: 1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-ol
• CAS NO: 326488-07-7
• Molecular Weight: 218.255
• Mol File: 326488-07-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-ol(326488-07-7)
• EPA Substance Registry System: 1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-ol(326488-07-7)

Safety Data

• Hazardous Substances Data: 326488-07-7(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 140-69-2 4-methoxybenzylhydrazine 
• 1193354-87-8 C₁₉H₁₆F₂N₂O₃ 
• 1193354-83-4 C₁₉H₁₈N₂O₃ 

Downstream Products

• 412327-09-4 [5-hydroxy-1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-4-yl]-phenyl-methanone 
• 1193354-88-9 C₂₀H₁₈F₂N₂O₃ 
• 1193354-83-4 C₁₉H₁₈N₂O₃ 
• 1193354-87-8 C₁₉H₁₆F₂N₂O₃ 

Relevant articles and documents

Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

West Nile Virus (WNV) is a potentially deadly mosquito-borne flavivirus which has spread rapidly throughout the world. Currently there is no effective vaccine against flaviviral infections. We previously reported the identification of pyrazole ester derivatives as allosteric inhibitors of WNV NS2B-NS3 proteinase. These compounds degrade rapidly in pH 8 buffer with a half life of 1-2 h. We now report the design, synthesis and in vitro evaluation of pyrazole derivatives that are inhibitors of WNV NS2B-NS3 proteinase with greatly improved stability in the assay medium.