326856-43-3

Basic information

• Product Name: 17β-hydroxy-7α-(9-carboxynonyl)-5α-androstan-3-one
• Synonyms: 17β-hydroxy-7α-(9-carboxynonyl)-5α-androstan-3-one
• CAS NO: 326856-43-3
• Molecular Weight: 460.698
• Mol File: 326856-43-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 17β-hydroxy-7α-(9-carboxynonyl)-5α-androstan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-hydroxy-7α-(9-carboxynonyl)-5α-androstan-3-one(326856-43-3)
• EPA Substance Registry System: 17β-hydroxy-7α-(9-carboxynonyl)-5α-androstan-3-one(326856-43-3)

Safety Data

• Hazardous Substances Data: 326856-43-3(Hazardous Substances Data)

Upstream product

• 20731-23-1 methyl non-8-enoate 

Relevant articles and documents

Discovery of 7α-substituted dihydrotestosterones as androgen receptor pure antagonists and their structure-activity relationships

A series of 7α-substituted dihydrotestosterone derivatives were synthesized and evaluated for androgen receptor (AR) pure antagonistic activity. From reporter gene assay (RGA), the compound with a side chain containing N-n-butyl-N-methyl amide (19a) showed pure antagonistic activity (IC50 = 340 nM, FI5 > 10,000 nM), whereas known AR antagonists showed partial agonistic activities. The optimization of 19a led to compound 23 (CH4892280), which showed more potent pure antagonistic activity (IC50 = 190 nM, FI5 > 10,000 nM). The SARs of tested compounds suggested that the length of the side chain and the substituents on the amide nitrogen are important for pure antagonistic activities.