32686-54-7

Basic information

• Product Name: Benzene, 1-chloro-3-isocyano- (9CI)
• Synonyms: Benzene, 1-chloro-3-isocyano- (9CI)
• CAS NO: 32686-54-7
• Molecular Formula: C₇H₄ClN
• Molecular Weight: 137.56636
• Product Categories: ISONITRITE
• Mol File: 32686-54-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzene, 1-chloro-3-isocyano- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-3-isocyano- (9CI)(32686-54-7)
• EPA Substance Registry System: Benzene, 1-chloro-3-isocyano- (9CI)(32686-54-7)

Safety Data

• Hazardous Substances Data: 32686-54-7(Hazardous Substances Data)

Upstream product

• 67-66-3 chloroform 
• 108-42-9 3-chloro-aniline 
• 57668-47-0 (3-chlorophenyl)carbonimidic dichloride 
• 4947-89-1 1-(3-chlorophenyl)-2-thiourea 
• 139-71-9 m-chloroformanilide 

Downstream Products

• 74752-17-3 [1-Aziridin-1-yl-meth-(Z)-ylidene]-(3-chloro-phenyl)-amine 
• 74739-80-3 (3-Chloro-phenyl)-[1-pyrrolidin-1-yl-meth-(Z)-ylidene]-amine 
• 74755-76-3 (3-Chloro-phenyl)-[1-piperidin-1-yl-meth-(Z)-ylidene]-amine 
• 74739-42-7 (3-Chloro-phenyl)-[1-morpholin-4-yl-meth-(Z)-ylidene]-amine 
• 74407-99-1 N'-(3-Chloro-phenyl)-N,N-dimethyl-formamidine 
• 74739-57-4 N'-(3-Chloro-phenyl)-N,N-diethyl-formamidine 
• 56638-74-5 1-(dimethylaminomethyleneamino)-3-chlorobenzene 
• 74739-68-7 [1-Aziridin-1-yl-meth-(E)-ylidene]-(3-chloro-phenyl)-amine 
• 74739-56-3 N'-(3-Chloro-phenyl)-N,N-diethyl-formamidine 
• 74739-79-0 (3-Chloro-phenyl)-[1-pyrrolidin-1-yl-meth-(E)-ylidene]-amine 
• 74755-75-2 (3-Chloro-phenyl)-[1-piperidin-1-yl-meth-(E)-ylidene]-amine 
• 74739-41-6 (3-Chloro-phenyl)-[1-morpholin-4-yl-meth-(E)-ylidene]-amine 
• 15531-14-3 Cr(CNC₆H₄Cl-m)6 
• 16065-83-1 chromium (III) ion 

Relevant articles and documents

Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Bromodomain-containing Protein 4 (BRD4), an ‘epigenetic reader’, regulates chromatin structure and gene expression via recognizing and binding acetylated lysine in histones. BRD4 has become a therapeutic target for cancers because it promotes the expression of the tumor genes, such as c-Myc, NF-κB, and Bcl-2. In this study, a new series of 3-methyl-1H-indazole derivatives were designed via virtual screening and structure-based optimization. All compounds were synthesized and evaluated for their inhibitory activities to BRD4-BD1 and their antiproliferative effects in cancer cell lines. Among them, several compounds (such as 9d, 9u and 9w) exhibited strong BRD4-BD1 affinities and inhibition activities, and potently suppressed MV4;11 cancer cell line proliferation. Among them, compound 9d showed excellent selectivity for BRD4 and effectively suppressed c-Myc, the downstream protein of BRD4. This study provided new lead compounds for further biological evaluation on BRD4.

THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.