327-51-5 Usage
Description
1,4-Dibromo-2,5-difluorobenzene is an organic compound characterized by its white adhering crystal form. It consists of a benzene ring with two bromine atoms attached to the 1st and 4th carbon positions, and two fluorine atoms attached to the 2nd and 5th carbon positions.
Uses
1. Used in Chemical Synthesis:
1,4-Dibromo-2,5-difluorobenzene is used as a key intermediate in the synthesis of various complex organic compounds due to its reactive bromine and fluorine substituents. Its ability to participate in electrophilic and nucleophilic reactions makes it a versatile building block in organic chemistry.
2. Used in Pharmaceutical Industry:
1,4-Dibromo-2,5-difluorobenzene is used as a starting material for the development of novel pharmaceutical compounds. Its unique structure and reactivity allow for the creation of new molecules with potential therapeutic applications.
3. Used in Material Science:
a) In the preparation of 1,2,4,5-tetrakis(phosphino)-3,6-difluorobenzenes, 1,4-Dibromo-2,5-difluorobenzene serves as a precursor for the synthesis of phosphine-containing ligands, which are essential in homogeneous catalysis and coordination chemistry.
b) In the preparation of poly(2,5-difluoro-2',5'-didodecyl-4,4'-biphenylylene), 1,4-Dibromo-2,5-difluorobenzene is used to create polymers with specific properties, such as enhanced thermal stability and chemical resistance, for applications in various industries, including electronics and automotive.
These applications highlight the importance of 1,4-Dibromo-2,5-difluorobenzene as a versatile compound with potential uses in various fields, including pharmaceuticals, material science, and chemical synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 327-51-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,2 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 327-51:
(5*3)+(4*2)+(3*7)+(2*5)+(1*1)=55
55 % 10 = 5
So 327-51-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H2Br2F2/c7-3-1-5(9)4(8)2-6(3)10/h1-2H
327-51-5Relevant articles and documents
Bromination of aromatic compounds using an Fe2O 3/zeolite catalyst
Nishina, Yuta,Takami, Keishi
supporting information, p. 2380 - 2383 (2013/02/21)
The catalytic bromination of non-activated aromatic compounds has been achieved using an Fe2O3/zeolite catalyst system. FeBr 3 was identified as the catalytic species, formed in situ from HBr and Fe2O3. The catalyst was easy-to-handle and cost effective and could also be recycled. The reaction system was also amenable to the one-pot sequential bromination/C-C bond formation of benzene.
PHOTOCHEMICAL BROMINATION OF ARENES. 2. FLUOROBENZENE DERIVATIVES (1)
Bolton, Roger,Owen, Elaine S. E.
, p. 393 - 406 (2007/10/02)
Photochemically induced reaction of fluorobenzene and a range of polyfluorobenzenes, both in an excess of the arene and with fluorotrichloromethane as solvent, gave isolable adducts only with fluorobenzene, the isomeric difluorobenzenes, and in very small yield with 1,3,5-trifluorobenzene.These adducts were identified by combustion analysis, mass spectrometry, and n.m.r. techniques (1H, 13C, 19F).In every case, the expected substitution products accompanied these adducts, and in the more fully fluorinated benzene derivatives substitution was the only process observed.Fluorotrichloromethane encouraged the formation of adducts, but the concurrent formation of substantial amounts of substitution products suggested that adducts are not the necessary precursors of the substitution products, in contrast with other systems.
