32710-88-6Relevant articles and documents
2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists
Andrés, Miriam,Bravo, Mónica,Buil, Maria Antonia,Calbet, Marta,Castro, Jordi,Domènech, Teresa,Eichhorn, Peter,Ferrer, Manel,Gómez, Elena,Lehner, Martin D.,Moreno, Imma,Roberts, Richard S.,Sevilla, Sara
, p. 3349 - 3353 (2013/06/27)
High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.
Pyrazol-4-acetic acid compounds
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, (2008/06/13)
Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.