327175-79-1Relevant articles and documents
Copper-Catalyzed Enantioselective Alkylation of Enolizable Ketimines with Organomagnesium Reagents
Ortiz, Pablo,Collados, Juan F.,Jumde, Ravindra P.,Otten, Edwin,Harutyunyan, Syuzanna R.
, p. 3041 - 3044 (2017)
Inexpensive and readily available organomagnesium reagents were used for the catalytic enantioselective alkylation of enolizable N-sulfonyl ketimines. The low reactivity and competing enolization of the ketimines was overcome by the use of a copper–phosphine chiral catalyst, which also rendered the transformation highly chemoselective and enantioselective for a broad range of ketimine substrates.
Direct Synthesis of Enolizable N-Sulfonyl Ketimines under Microwave Irradiation
Ortiz, Pablo,Collados, Juan F.,Harutyunyan, Syuzanna R.
supporting information, p. 1247 - 1250 (2016/03/19)
N-sulfonyl imines are widely used as substrates for a range of transformations. Access to N-sulfonyl aldimines is straightforward through direct condensation between the parent aldehyde and the sulfonamide. However, this approach is not efficient for the