32724-04-2

Basic information

• Product Name: 3-(4-chloro-phenyl)-1-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propynone cyclohemiacetal
• Synonyms: 3-(4-chloro-phenyl)-1-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propynone cyclohemiacetal
• CAS NO: 32724-04-2
• Molecular Weight: 298.769
• Mol File: 32724-04-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-chloro-phenyl)-1-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propynone cyclohemiacetal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chloro-phenyl)-1-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propynone cyclohemiacetal(32724-04-2)
• EPA Substance Registry System: 3-(4-chloro-phenyl)-1-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propynone cyclohemiacetal(32724-04-2)

Safety Data

• Hazardous Substances Data: 32724-04-2(Hazardous Substances Data)

Upstream product

• 1689-09-4 3,3-Dimethyl-3H-isobenzofuran-1-one 
• 62440-19-1 lithium 4-chlorophenylacetylide 

Downstream Products

• 32724-10-0 4-[1-(4-chloro-phenyl)-2-(3,3-dimethyl-3H-isobenzofuran-1-ylidene)-ethylidene]-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 

Relevant articles and documents

Oxidative Kinetic Resolution of Cyclic Benzylic Ethers

A manganese-catalyzed oxidative kinetic resolution of cyclic benzylic ethers through asymmetric C(sp3)?H oxidation is reported. The practical approach is applicable to a wide range of 1,3-dihydroisobenzofurans bearing diverse functional groups and substituent patterns at the α position with extremely efficient enantiodiscrimination. The generality of the strategy was further demonstrated by efficient oxidative kinetic resolution of another type of five-membered cyclic benzylic ether, 2,3-dihydrobenzofurans, and six-membered 6H-benzo[c]chromenes. Direct late-stage oxidative kinetic resolution of bioactive molecules that are otherwise difficult to access was further explored.