3279-76-3 Usage
Description
2-Hydroxy-6-methylpyridine is an organic compound that is characterized by its white to cream-colored crystalline powder appearance. It is known for its ability to react with carboxylic acids, such as RCOOH, to form an equilibrium mixture of products. In this reaction, the anion mhp is formed from the deprotonation of 2-hydroxy-6-methylpyridine, and the products include M(2)(O(2)CR)(n)(mhp)(4-n), where R can be 2-thienyl or phenyl.
Uses
Used in Chemical Synthesis:
2-Hydroxy-6-methylpyridine is used as a reagent in the chemical synthesis industry for the formation of various compounds. Its ability to react with carboxylic acids makes it a valuable component in the creation of new molecules with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Hydroxy-6-methylpyridine is used as a starting material for the development of new drugs. Its unique chemical properties allow it to be a key component in the synthesis of various medicinal compounds, potentially leading to the discovery of novel therapeutic agents.
Used in Material Science:
2-Hydroxy-6-methylpyridine can be utilized in the field of material science as a component in the development of new materials with specific properties. Its reactivity with carboxylic acids can be exploited to create materials with tailored characteristics for various applications, such as in electronics, coatings, or adhesives.
Used in Analytical Chemistry:
As a white to cream-colored crystalline powder, 2-Hydroxy-6-methylpyridine can be employed in analytical chemistry for the identification and quantification of specific compounds. Its distinct chemical properties make it a useful reference material or standard in various analytical techniques, such as chromatography or spectroscopy.
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 1186, 1949 DOI: 10.1021/ja01172a014
Check Digit Verification of cas no
The CAS Registry Mumber 3279-76-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,2,7 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3279-76:
(6*3)+(5*2)+(4*7)+(3*9)+(2*7)+(1*6)=103
103 % 10 = 3
So 3279-76-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H7NO/c1-5-3-2-4-6(8)7-5/h2-4H,1H3,(H,7,8)
3279-76-3Relevant articles and documents
Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents
Peng, Panfeng,Wang, Jiang,Jiang, Hualiang,Liu, Hong
, p. 5376 - 5379 (2016)
In this study we developed a method for the pyridine-directed, rhodium-catalyzed, site-selective C-H alkylation and arylation of pyridones using commercially available trifluoroborate reagents. This simple and versatile transformation proceeded smoothly under relatively mild conditions with perfect site selectivity. The coupling groups in the boron reagents can be extended to primary alkyl, benzyl, and cycloalkyl. Moreover, direct C-H arylation products could also be obtained under similar conditions.
Rh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides
Fan, Qinghua,Li, Bohan,Li, Huanrong,Walsh, Patrick J.,Xu, Lijin,Xu, Xin,Xu, Xingyu,Yu, Haiyang,Zhao, Haoqiang
supporting information, p. 4228 - 4234 (2020/06/27)
A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for the efficient synthesis of various C6-alkylated 2-pyridones with good functional group tolerance.
Synthesis of 4-, 5-, and 6-methyl-2,2'-bipyridine by a negishi cross-coupling strategy: 5-Methyl-2,2'-bipyridine: [2,2'-bipyridine, 5-methyl-]
Smith, Adam P.,Savage, Scott A.,Love, J. Christopher,Fraser, Cassandra L.,Kuester, Erik,Hegedus, Louis S.
, p. 51 - 51 (2017/09/23)
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