327994-59-2

Basic information

• Product Name: 9-Phenyl-2H-[1,2,4]oxadiazolo[3,2-b]quinazolin-2-one
• CAS NO: 327994-59-2
• Molecular Weight: 263.255
• Mol File: 327994-59-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-Phenyl-2H-[1,2,4]oxadiazolo[3,2-b]quinazolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Phenyl-2H-[1,2,4]oxadiazolo[3,2-b]quinazolin-2-one(327994-59-2)
• EPA Substance Registry System: 9-Phenyl-2H-[1,2,4]oxadiazolo[3,2-b]quinazolin-2-one(327994-59-2)

Safety Data

• Hazardous Substances Data: 327994-59-2(Hazardous Substances Data)

Upstream product

• 51674-05-6 1-(2-Aminophenyl)-1-phenyl-methanonoxim 
• 327994-46-7 Ethyl 3-oxido-4-phenylquinazolin-2-ylcarbamate 

Relevant articles and documents

3,9-Dihydro-2H-[1,2,4]-oxadiazolo[3,2-b]quinazolin-2-ones: First synthesis of the parent heterocycle, 7- and 9-substituted derivatives

A first synthesis of 3,9-dihydro-9-aryl-2H-[1,2,4]-oxadiazolo[3,2-b]quinazolin-2-ones is described via the thermal cyclisation of ethyl-(4-aryl-3-oxido-2-quinazolinyl)-carbamates followed by borohydride reduction. A more direct route to 3,9-dihydro-2H-[1,2,4]-oxadiazolo[3,2-b]quinazolin-2-ones, involving the reductive-ring closure of ethyl-(3-oxido-2-quinazolinyl)-carbamate, gives access to the parent unsubstituted heterocycle in good yield. This reaction has been extended to a variety of 7- and 9-substituted 3,9-dihydro-2H-[1,2,4]-oxadiazolo[3,2-b]quinazolin-2-ones.