328-68-7

Basic information

• Product Name: 3-Amino-5-(trifluoromethyl)benzoic acid
• Synonyms: 3-Amino-5-carboxybenzotrifluoride, 3-Carboxy-5-(trifluoromethyl)aniline;BUTTPARK 25\01-23;3-AMINO-5-(TRIFLUOROMETHYL)BENZOIC ACID;3-Amino-5-(trifluoromethyl)benzoic acid 97%;3-AMINO-5-(TRIFLUOROEMTHYL)BENZOIC ACID;3-Amino-5-(trifluoromethyl)benzoicacid97%
• CAS NO: 328-68-7
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.13
• Product Categories: Fluorine series;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Aromatic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 328-68-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 141-146 °C(lit.)
• Boiling Point: 331.9°Cat760mmHg
• Flash Point: 154.5°C
• Appearance: /
• Density: 1.489g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.93±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-5-(trifluoromethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-5-(trifluoromethyl)benzoic acid(328-68-7)
• EPA Substance Registry System: 3-Amino-5-(trifluoromethyl)benzoic acid(328-68-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: DD6205700
• HazardClass: IRRITANT
• Hazardous Substances Data: 328-68-7(Hazardous Substances Data)

Usage

General Description

3-Amino-5-(trifluoromethyl)benzoic acid is a chemical compound that belongs to the class of organic compounds known as trifluoromethylbenzenes. These organic compounds contain a benzene ring substituted with one or more trifluoromethyl groups. 3-Amino-5-(trifluoromethyl)benzoic acid features a trifluoromethyl group and an amino group attached to a benzene ring, along with a carboxylic acid group. Because of its molecular structure, it has variety of potential applications in the field of chemistry. Its physical properties may vary depending on the specific conditions such as temperature, pressure, concentration, or pH. This chemical compound is also of research interest in the field of synthetic organic chemistry.

Upstream product

• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 

Downstream Products

• 955947-15-6 3-isothiocyanato-5-trifluoromethyl-benzoic acid 
• 955953-25-0 3-(2-carbamoyl-2-cyano-thioacetylamino)-5-trifluoromethyl-benzoic acid 
• 53604-84-5 3-chlorosulfonyl-5-(trifluoromethyl)benzoic acid 
• 157383-40-9 5-trifluoromethyl-3-N, N-dimethylaminobenzoylguanidine hydrochloride 
• 328-69-8 3-hydroxy-5-(trifluoromethyl)benzoic acid 
• 328-67-6 3-bromo-5-(trifluoromethyl)benzoic acid 
• 900799-10-2 3-benzyloxycarbonylamino-5-trifluoromethyl-benzoic acid 
• 1044272-24-3 3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-trifluoromethyl-benzoic acid 
• 53985-49-2 3-chloro-5-(trifluoromethyl)benzoic acid 
• 942077-27-2 3-(tert-butyl-dimethyl-silanyloxymethyl)-5-trifluoromethyl-phenylamine 
• 1229454-66-3 3-amino-N-isopropyl-5-(trifluoromethyl)benzamide 
• 1247019-14-2 (R)-3-(amino)-N-(1-phenylethyl)-5-(trifluoromethyl)benzamide 
• 1357582-09-2 3-amino-N-[3-(1H-tetrazol-5-yl)-phenyl]-5-trifluoromethyl-benzamide 
• 161622-13-5 3-azido-5-trifluoromethylbenzoic acid 

Relevant articles and documents

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Catalytic Asymmetric Synthesis of Quaternary Barbituric Acids

The catalytic asymmetric α-functionalization of prochiral barbituric acids, a subtype of pseudosymmetric 1,3-diamides, to yield the corresponding 5,5-disubstituted (quaternary) derivatives remains essentially unsolved. In this study 2-alkylthio-4,6-dioxopirimidines are designed as key 1,3-diamide surrogates that perform exceedingly in amine-squaramide catalyzed C-C bond forming reactions with vinyl ketones or Morita-Baylis-Hillmann-type allyl bromides as electrophiles. Mild acid hydrolysis of adducts affords barbituric acid derivatives with an in-ring quaternary carbon in unprecedented enantioselectivity, offering valuable materials for biological evaluations.

PIPERIDINE DERIVATIVE AND USE THEREOF

The present invention provides a novel piperidine derivative and a tachykinin receptor antagonist containing same, as well as a compound represented by the formula:wherein R1 is carbamoylmethyl, methylsulfonylethylcarbonyl and the like; R2 is methyl or cyclopropyl; R3 is a hydrogen atom or methyl; R4 is a chlorine atom or trifluoromethyl; R5 is a chlorine atom or trifluoromethyl; and a group represented by the formula:is a group represented by the formula:wherein R6 is a hydrogen atom, methyl, ethyl or isopropyl; R7 is a hydrogen atom, methyl or a chlorine atom; and R8 is a hydrogen atom, a fluorine atom, a chlorine atom or methyl; or 3-methylthiophen-2-yl, and a salt thereof.