328062-45-9Relevant articles and documents
MTA-Cooperative PRMT5 Inhibitors
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Paragraph 0253; 0254, (2021/03/19)
The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds
Mu, Bing,Li, Jingya,Zou, Dapeng,Wu, Yusheng,Chang, Junbiao,Wu, Yangjie
supporting information, p. 5260 - 5263 (2016/11/02)
The first Pd-catalyzed tandem cyclization of imidazo[1,2-a]pyridines with 2-chlorobenzaldehydes through C-H arylation and acylation is presented for the efficient synthesis of novel 6H-benzo[b]imidazo[5,1,2-de]quinolizin-6-ones. The direct acylation react
(Hetero)arylation of 6-halogenoimidazo[1,2-a]pyridines differently substituted at C(2): Influence of the 2-substituent on the Suzuki cross-coupling reaction
Enguehard, Cecile,Hervet, Maud,Thery, Isabelle,Renou, Jean-Louis,Fauvelle, Florence,Gueiffier, Alain
, p. 3610 - 3615 (2007/10/03)
We previously reported that reactivity towards the Suzuki cross-coupling reaction of 3-iodoimidazo[1,2-a]pyridines substituted at C(2) is largely influenced by the nature of this 2-substituent. Hence, with the aim to expand the scope of this coupling proc